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ALOX5 arachidonate 5-lipoxygenase [ Canis lupus familiaris (dog) ]

Gene ID: 477753, updated on 5-Mar-2024

Summary

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Official Symbol
ALOX5provided by VGNC
Official Full Name
arachidonate 5-lipoxygenaseprovided by VGNC
Primary source
VGNC:VGNC:37813
See related
Ensembl:ENSCAFG00845026331
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 28
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 28 NC_051832.1 (2349844..2407164, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 28 NC_006610.4 (2405370..2462571, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 28 NC_049249.1 (2315780..2373040, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 28 NC_049288.1 (2147070..2204281, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 28 NC_049769.1 (2183953..2241179, complement)

Chromosome 28 - NC_051832.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene olfactory receptor family 13 subfamily A member 1 Neighboring gene olfactory receptor family 6 subfamily D member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and antibody recognition analysis of the canine 5-lipoxygenase gene. Loftus JP, et al. Vet Immunol Immunopathol, 2011 Aug 15. PMID 21616545
  2. Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. Lascelles BD, et al. J Orthop Res, 2009 Sep. PMID 19274754
  3. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. Flamand N, et al. J Biol Chem, 2009 Jan 2. PMID 18978352, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There was no significant difference in COX-1 or LOX protein in osteoarthritis hip joints
    Title: Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
  2. nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis.
    Title: Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 5-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polyunsaturated fatty acid 5-lipoxygenase
NP_001192042.1
XP_038295557.1
XP_038295558.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205113.1 → NP_001192042.1  polyunsaturated fatty acid 5-lipoxygenase

    See identical proteins and their annotated locations for NP_001192042.1

    Status: PROVISIONAL

    Source sequence(s)
    HQ657323
    UniProtKB/TrEMBL
    A0A8C0NZM6, A0A8P0TP16, E7ECW0
    Related
    ENSCAFP00845036492.1, ENSCAFT00845046482.1
    Conserved Domains (2) summary
    cd01753
    Location:2 → 115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227 → 667
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051832.1 Reference ROS_Cfam_1.0

    Range
    2349844..2407164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038439629.1 → XP_038295557.1  polyunsaturated fatty acid 5-lipoxygenase isoform X1

    UniProtKB/TrEMBL
    A0A8C0NZM6, A0A8P0TP16
    Conserved Domains (2) summary
    pfam00305
    Location:183 → 621
    Lipoxygenase
    cl00011
    Location:2 → 79
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

  2. XM_038439630.1 → XP_038295558.1  polyunsaturated fatty acid 5-lipoxygenase isoform X2

    UniProtKB/TrEMBL
    A0A8C0NZM6, A0A8P0TP16
    Conserved Domains (1) summary
    pfam00305
    Location:115 → 553
    Lipoxygenase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049288.1 Alternate UMICH_Zoey_3.1

    Range
    2147070..2204281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049769.1 Alternate UNSW_CanFamBas_1.0

    Range
    2183953..2241179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049249.1 Alternate UU_Cfam_GSD_1.0

    Range
    2315780..2373040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006610.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2405370..2462571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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