U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EPS8 EGFR pathway substrate 8, signaling adaptor [ Canis lupus familiaris (dog) ]

Gene ID: 477686, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
EPS8provided by VGNC
Official Full Name
EGFR pathway substrate 8, signaling adaptorprovided by VGNC
Primary source
VGNC:VGNC:40427
See related
Ensembl:ENSCAFG00845019921
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 27
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (31213204..31391094)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (15378134..15554665, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (15100205..15276688, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (31212841..31279922)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (31058974..31235537)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene deoxyribose-phosphate aldolase Neighboring gene serine/threonine kinase receptor associated protein Neighboring gene 40S ribosomal protein S3a-like Neighboring gene uncharacterized LOC102153146 Neighboring gene protein tyrosine phosphatase receptor type O Neighboring gene uncharacterized LOC111092826

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
epidermal growth factor receptor kinase substrate 8; LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8
Names
epidermal growth factor receptor pathway substrate 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    31213204..31391094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438902.1 → XP_038294830.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Related
    ENSCAFP00845027641.1, ENSCAFT00845035317.1
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038438905.1 → XP_038294833.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0THS5
    Conserved Domains (3) summary
    cd09540
    Location:735 → 799
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:550 → 603
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_038438906.1 → XP_038294834.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K221, A0A8I3P8R5
    Related
    ENSCAFP00845027782.1, ENSCAFT00845035505.1
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_038438908.1 → XP_038294836.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K221, A0A8I3P8R5
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_038438907.1 → XP_038294835.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_038438903.1 → XP_038294831.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_038438904.1 → XP_038294832.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    31212841..31279922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513564.1 → XP_038369492.1  LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    31058974..31235537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038641379.1 → XP_038497307.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038641382.1 → XP_038497310.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    Conserved Domains (3) summary
    cd09540
    Location:735 → 799
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:550 → 603
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_038641383.1 → XP_038497311.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_038641385.1 → XP_038497313.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_038641384.1 → XP_038497312.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_038641380.1 → XP_038497308.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_038641381.1 → XP_038497309.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    15100205..15276688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038576909.1 → XP_038432837.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K221, A0A8I3P8R5
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038576908.1 → XP_038432836.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0THS5
    Conserved Domains (3) summary
    cd09540
    Location:735 → 799
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:550 → 603
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_038576905.1 → XP_038432833.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_038576910.1 → XP_038432838.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_038576906.1 → XP_038432834.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_038576907.1 → XP_038432835.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8I3PC29
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_038576911.1 → XP_038432839.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K221, A0A8I3P8R5
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15378134..15554665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038459850.1 → XP_038315778.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PST0, A0A8P0P394
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_038459849.1 → XP_038315777.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0THS5
    Conserved Domains (3) summary
    cd09540
    Location:735 → 799
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:550 → 603
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  3. XM_038459846.1 → XP_038315774.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8P0STP5
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_038459851.1 → XP_038315779.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8P0STP5
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  5. XM_038459847.1 → XP_038315775.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8P0STP5
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  6. XM_038459848.1 → XP_038315776.1  epidermal growth factor receptor kinase substrate 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0THS5, A0A8P0STP5
    Conserved Domains (3) summary
    cd09540
    Location:736 → 800
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:551 → 604
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:81 → 208
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  7. XM_022411359.2 → XP_022267067.1  epidermal growth factor receptor kinase substrate 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PST0, A0A8P0P394
    Conserved Domains (3) summary
    cd09540
    Location:719 → 783
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:534 → 587
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.