KRT18 keratin 18 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KRT18provided by VGNC
Official Full Name: keratin 18provided by VGNC
Primary source: VGNC:VGNC:106506
See related: Ensembl:ENSCAFG00845023645
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CK18
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 27

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	27	NC_051831.1 (2190002..2194108, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	27	NC_006609.4 (44058883..44062982)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	27	NC_049248.1 (44457950..44461835)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	27	NC_049287.1 (2207095..2210994, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	27	NC_049768.1 (2193381..2197266, complement)

Chromosome 27 - NC_051831.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemically, 50% or more of the canine prostate cancer cases showed expression of PSA, PSMA, UPIII, CK7, CK5, CK14, and CK18.
Title: Histopathological and immunohistochemical characterization of canine prostate cancer.
Canine prostate epithelium displayed a highly differentiated character, with most cells expressing CK18 and PSA. After castration, prostate epithelium regressed, and the tubule cells showed a ductal phenotype of CK5, CK18, and CK7.
Title: Comparative characterization of the canine normal prostate in intact and castrated animals.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intermediate filament cytoskeleton organization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in keratin filament	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: keratin, type I cytoskeletal 18

Names: cytokeratin 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.