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PTPN11 protein tyrosine phosphatase non-receptor type 11 [ Canis lupus familiaris (dog) ]

Gene ID: 477488, updated on 5-Mar-2024

Summary

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Official Symbol
PTPN11provided by VGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 11provided by VGNC
Primary source
VGNC:VGNC:45168
See related
Ensembl:ENSCAFG00845021271
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
SHP-2
Orthologs
human mouse all
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Genomic context

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See PTPN11 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 26 NC_051830.1 (10229100..10311852)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 26 NC_006608.4 (10107654..10190288)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 26 NC_049247.1 (10314568..10397234)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 26 NC_049286.1 (10203528..10286110)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 26 NC_049767.1 (10266437..10349406)

Chromosome 26 - NC_051830.1Genomic Context describing neighboring genes Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene uncharacterized LOC119866153 Neighboring gene ribosomal protein L6 Neighboring gene uncharacterized LOC119866090 Neighboring gene uncharacterized LOC111092664

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTPN11 mutations in canine and human disseminated histiocytic sarcoma. Hédan B, et al. Int J Cancer, 2020 Sep 15. PMID 32212266
  2. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Wang CZ, et al. Mol Biol Cell, 2006 Jun. PMID 16611743, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
    Title: PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
XP_005636307.1
XP_005636308.1
XP_038292668.1
XP_038292669.1
XP_038367582.1
XP_038367583.1
XP_038431076.1
XP_038431077.1
XP_038495260.1
XP_038495261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051830.1 Reference ROS_Cfam_1.0

    Range
    10229100..10311852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038436740.1 → XP_038292668.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TMZ0, A0A8I3PMT9
    Related
    ENSCAFP00845029515.1, ENSCAFT00845037668.1
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  2. XM_038436741.1 → XP_038292669.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TMZ0, A0A8I3P833
    Related
    ENSCAFP00845029696.1, ENSCAFT00845037897.1
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049286.1 Alternate UMICH_Zoey_3.1

    Range
    10203528..10286110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038511654.1 → XP_038367582.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  2. XM_038511655.1 → XP_038367583.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049767.1 Alternate UNSW_CanFamBas_1.0

    Range
    10266437..10349406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038639332.1 → XP_038495260.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  2. XM_038639333.1 → XP_038495261.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049247.1 Alternate UU_Cfam_GSD_1.0

    Range
    10314568..10397234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038575148.1 → XP_038431076.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TMQ6, A0A8C0TMZ0
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  2. XM_038575149.1 → XP_038431077.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    UniProtKB/TrEMBL
    A0A4D6PF96, A0A8C0TMZ0
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006608.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10107654..10190288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005636250.3 → XP_005636307.1  tyrosine-protein phosphatase non-receptor type 11 isoform X1

    UniProtKB/TrEMBL
    A0A8C0TMQ6, A0A8C0TMZ0
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 528
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11

  2. XM_005636251.3 → XP_005636308.1  tyrosine-protein phosphatase non-receptor type 11 isoform X2

    UniProtKB/TrEMBL
    A0A4D6PF96, A0A8C0TMZ0
    Conserved Domains (3) summary
    cd09931
    Location:111 → 218
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5 → 103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd14605
    Location:272 → 524
    PTPc-N11; catalytic domain of tyrosine-protein phosphatase non-receptor type 11
Nucleotide Protein
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