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ITCH itchy E3 ubiquitin protein ligase [ Canis lupus familiaris (dog) ]

Gene ID: 477199, updated on 5-Mar-2024

Summary

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Official Symbol
ITCHprovided by VGNC
Official Full Name
itchy E3 ubiquitin protein ligaseprovided by VGNC
Primary source
VGNC:VGNC:42117
See related
Ensembl:ENSCAFG00845015881
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (24168489..24321093)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (23124607..23276323)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (23990143..24142586)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (23456967..23608609)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (23551074..23703694)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene dynein light chain roadblock-type 1 Neighboring gene microtubule associated protein 1 light chain 3 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein K29-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase Itchy homolog
Names
itchy E3 ubiquitin protein ligase homolog
itchy homolog E3 ubiquitin protein ligase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    24168489..24321093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433558.1 → XP_038289486.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 830
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  2. XM_038433556.1 → XP_038289484.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  3. XM_038433555.1 → XP_038289483.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Related
    ENSCAFP00845022264.1, ENSCAFT00845028298.1
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  4. XM_038433557.1 → XP_038289485.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  5. XM_038433559.1 → XP_038289487.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    UniProtKB/TrEMBL
    A0A8P0PMA4
    Conserved Domains (4) summary
    COG5021
    Location:208 → 752
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:177 → 206
    WW; WW domain
    NF035936
    Location:47 → 159
    agg_sub_LPXTH; serine-rich aggregation substance UasX
    cl14603
    Location:1 → 30
    C2; C2 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    23456967..23608609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508741.1 → XP_038364669.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 830
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  2. XM_038508739.1 → XP_038364667.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  3. XM_038508738.1 → XP_038364666.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  4. XM_038508740.1 → XP_038364668.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  5. XM_038508742.1 → XP_038364670.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    Conserved Domains (4) summary
    COG5021
    Location:208 → 752
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:177 → 206
    WW; WW domain
    NF035936
    Location:47 → 159
    agg_sub_LPXTH; serine-rich aggregation substance UasX
    cl14603
    Location:1 → 30
    C2; C2 domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    23551074..23703694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038636303.1 → XP_038492231.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 830
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  2. XM_038636301.1 → XP_038492229.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  3. XM_038636300.1 → XP_038492228.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  4. XM_038636302.1 → XP_038492230.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  5. XM_038636304.1 → XP_038492232.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    Conserved Domains (4) summary
    COG5021
    Location:208 → 752
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:177 → 206
    WW; WW domain
    NF035936
    Location:47 → 159
    agg_sub_LPXTH; serine-rich aggregation substance UasX
    cl14603
    Location:1 → 30
    C2; C2 domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    23990143..24142586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038572050.1 → XP_038427978.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8P0PMA4

  2. XM_038572048.1 → XP_038427976.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8P0PMA4

  3. XM_038572047.1 → XP_038427975.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8P0PMA4

  4. XM_038572049.1 → XP_038427977.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8P0PMA4

  5. XM_038572051.1 → XP_038427979.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    UniProtKB/TrEMBL
    A0A8P0PMA4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23124607..23276323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005634950.4 → XP_005635007.1  E3 ubiquitin-protein ligase Itchy homolog isoform X2

    UniProtKB/TrEMBL
    A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 830
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  2. XM_038458028.1 → XP_038313956.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  3. XM_846367.6 → XP_851460.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  4. XM_022409130.2 → XP_022264838.1  E3 ubiquitin-protein ligase Itchy homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWX5, A0A8C0QEV6, A0A8I3NYH6, A0A8P0PMA4
    Conserved Domains (4) summary
    cd04021
    Location:17 → 140
    C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
    COG5021
    Location:318 → 862
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:287 → 316
    WW; WW domain
    NF035936
    Location:157 → 269
    agg_sub_LPXTH; serine-rich aggregation substance UasX

  5. XM_022409131.1 → XP_022264839.1  E3 ubiquitin-protein ligase Itchy homolog isoform X3

    UniProtKB/TrEMBL
    A0A8P0PMA4
    Conserved Domains (4) summary
    COG5021
    Location:208 → 752
    HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:177 → 206
    WW; WW domain
    NF035936
    Location:47 → 159
    agg_sub_LPXTH; serine-rich aggregation substance UasX
    cl14603
    Location:1 → 30
    C2; C2 domain
Nucleotide Protein
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