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BMP2 bone morphogenetic protein 2 [ Canis lupus familiaris (dog) ]

Gene ID: 477162, updated on 5-Mar-2024

Summary

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Official Symbol
BMP2provided by VGNC
Official Full Name
bone morphogenetic protein 2provided by VGNC
Primary source
VGNC:VGNC:38478
See related
Ensembl:ENSCAFG00845027004
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See BMP2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (15603929..15615829, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (15022880..15034779, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (15650158..15662056, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (15210353..15222261, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (15320936..15332831, complement)

Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106557686 Neighboring gene uncharacterized LOC106557669 Neighboring gene uncharacterized LOC111092122 Neighboring gene uncharacterized LOC111092142 Neighboring gene uncharacterized LOC119865627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tracheal cartilage regeneration and new bone formation by slow release of bone morphogenetic protein (BMP)-2. Igai H, et al. ASAIO J, 2008 Jan-Feb. PMID 18204324
  2. The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors. Klopfleisch R, et al. Vet Pathol, 2010 May. PMID 20375427

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the combined expression patterns of BMP2, LTBP4, and DERL1 (Derlin-1) correctly classified each individual tumor as benign or malignant.
    Title: The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors.
  2. bone morphogenetic protein (BMP)-2 has a role in tracheal cartilage regeneration and new bone formation
    Title: Tracheal cartilage regeneration and new bone formation by slow release of bone morphogenetic protein (BMP)-2.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables BMP receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bone morphogenetic protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051828.1 Reference ROS_Cfam_1.0

    Range
    15603929..15615829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038433175.1 → XP_038289103.1  bone morphogenetic protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JG46, A0A8I3PXE9, A0A8P0T128
    Related
    ENSCAFP00845037333.1, ENSCAFT00845047576.1
    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:43 → 266
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038433174.1 → XP_038289102.1  bone morphogenetic protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QCM6, A0A8P0NRN7
    Related
    ENSCAFP00845037348.1, ENSCAFT00845047596.1
    Conserved Domains (2) summary
    cd19390
    Location:329 → 431
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:79 → 302
    TGFb_propeptide; TGF-beta propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049284.1 Alternate UMICH_Zoey_3.1

    Range
    15210353..15222261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038508374.1 → XP_038364302.1  bone morphogenetic protein 2 isoform X2

    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:43 → 266
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038508373.1 → XP_038364301.1  bone morphogenetic protein 2 isoform X1

    Conserved Domains (2) summary
    cd19390
    Location:329 → 431
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:79 → 302
    TGFb_propeptide; TGF-beta propeptide

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

    Range
    15320936..15332831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038635895.1 → XP_038491823.1  bone morphogenetic protein 2 isoform X2

    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:43 → 266
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038635894.1 → XP_038491822.1  bone morphogenetic protein 2 isoform X1

    Conserved Domains (2) summary
    cd19390
    Location:329 → 431
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:79 → 302
    TGFb_propeptide; TGF-beta propeptide

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

    Range
    15650158..15662056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038571648.1 → XP_038427576.1  bone morphogenetic protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JG46, A0A8I3PXE9, A0A8P0T128
    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:43 → 266
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038571647.1 → XP_038427575.1  bone morphogenetic protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QCM6, A0A8P0NRN7
    Conserved Domains (2) summary
    cd19390
    Location:329 → 431
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:79 → 302
    TGFb_propeptide; TGF-beta propeptide

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15022880..15034779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_534351.7 → XP_534351.2  bone morphogenetic protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JG46, A0A8I3PXE9, A0A8P0T128
    Conserved Domains (2) summary
    cd19390
    Location:293 → 395
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:43 → 266
    TGFb_propeptide; TGF-beta propeptide

  2. XM_038458012.1 → XP_038313940.1  bone morphogenetic protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QCM6, A0A8P0NRN7
    Conserved Domains (2) summary
    cd19390
    Location:329 → 431
    TGF_beta_BMP2; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins
    pfam00688
    Location:79 → 302
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein
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