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KAT2B lysine acetyltransferase 2B [ Canis lupus familiaris (dog) ]

Gene ID: 477052, updated on 5-Mar-2024

Summary

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Official Symbol
KAT2Bprovided by VGNC
Official Full Name
lysine acetyltransferase 2Bprovided by VGNC
Primary source
VGNC:VGNC:42210
See related
Ensembl:ENSCAFG00845020587
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PCAF
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (23651391..23751080, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (23190019..23289543, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (23675265..23774811, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (23363816..23463316, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (23429027..23528696, complement)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly protein COX18, mitochondrial-like Neighboring gene shugoshin 1 Neighboring gene uncharacterized LOC119865372 Neighboring gene protein phosphatase 2C like domain containing 1 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene uncharacterized LOC119865373

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. Shakibaei M, et al. J Biol Chem, 2011 Apr 1. PMID 21239502, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells.
    Title: Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone acetyltransferase KAT2B; LOW QUALITY PROTEIN: histone acetyltransferase KAT2B
Names
p300/CBP-associated factor
XP_038288113.1
XP_038288114.1
XP_038288115.1
XP_038288116.1
XP_038288117.1
XP_038288118.1
XP_038313058.1
XP_038313059.1
XP_038313060.1
XP_038313061.1
XP_038313062.1
XP_038313063.1
XP_038363412.1
XP_038363413.1
XP_038363414.1
XP_038363415.1
XP_038363416.1
XP_038363417.1
XP_038426663.1
XP_038490845.1
XP_038490846.1
XP_038490847.1
XP_038490848.1
XP_038490849.1
XP_038490850.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    23651391..23751080 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432185.1 → XP_038288113.1  histone acetyltransferase KAT2B isoform X1

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Related
    ENSCAFP00845028537.1, ENSCAFT00845036461.1
    Conserved Domains (3) summary
    cd05509
    Location:740 → 839
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:500 → 839
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:87 → 338
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  2. XM_038432190.1 → XP_038288118.1  histone acetyltransferase KAT2B isoform X6

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:629 → 728
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:389 → 728
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:1 → 227
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  3. XM_038432186.1 → XP_038288114.1  histone acetyltransferase KAT2B isoform X2

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:735 → 834
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:495 → 834
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  4. XM_038432187.1 → XP_038288115.1  histone acetyltransferase KAT2B isoform X3

    UniProtKB/TrEMBL
    A0A8C0RRW4, A0A8I3S1Z4
    Related
    ENSCAFP00845028765.1, ENSCAFT00845036741.1
    Conserved Domains (3) summary
    cd05509
    Location:706 → 805
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:466 → 805
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:24 → 304
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  5. XM_038432188.1 → XP_038288116.1  histone acetyltransferase KAT2B isoform X4

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:702 → 801
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:462 → 801
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:20 → 300
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  6. XM_038432189.1 → XP_038288117.1  histone acetyltransferase KAT2B isoform X5

    UniProtKB/TrEMBL
    A0A8C0TKA3
    Conserved Domains (2) summary
    COG5076
    Location:495 → 660
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    23363816..23463316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507484.1 → XP_038363412.1  histone acetyltransferase KAT2B isoform X1

    Conserved Domains (3) summary
    cd05509
    Location:740 → 839
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:500 → 839
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:87 → 338
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  2. XM_038507489.1 → XP_038363417.1  histone acetyltransferase KAT2B isoform X6

    Conserved Domains (3) summary
    cd05509
    Location:629 → 728
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:389 → 728
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:1 → 227
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  3. XM_038507485.1 → XP_038363413.1  histone acetyltransferase KAT2B isoform X2

    Conserved Domains (3) summary
    cd05509
    Location:735 → 834
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:495 → 834
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  4. XM_038507486.1 → XP_038363414.1  histone acetyltransferase KAT2B isoform X3

    Conserved Domains (3) summary
    cd05509
    Location:706 → 805
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:466 → 805
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:24 → 304
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  5. XM_038507487.1 → XP_038363415.1  histone acetyltransferase KAT2B isoform X4

    Conserved Domains (3) summary
    cd05509
    Location:702 → 801
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:462 → 801
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:20 → 300
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  6. XM_038507488.1 → XP_038363416.1  histone acetyltransferase KAT2B isoform X5

    Conserved Domains (2) summary
    COG5076
    Location:495 → 660
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    23429027..23528696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038634917.1 → XP_038490845.1  histone acetyltransferase KAT2B isoform X1

    Conserved Domains (3) summary
    cd05509
    Location:740 → 839
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:500 → 839
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:87 → 338
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  2. XM_038634922.1 → XP_038490850.1  histone acetyltransferase KAT2B isoform X6

  3. XM_038634918.1 → XP_038490846.1  histone acetyltransferase KAT2B isoform X2

  4. XM_038634919.1 → XP_038490847.1  histone acetyltransferase KAT2B isoform X3

  5. XM_038634920.1 → XP_038490848.1  histone acetyltransferase KAT2B isoform X4

  6. XM_038634921.1 → XP_038490849.1  histone acetyltransferase KAT2B isoform X5

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    23675265..23774811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038570735.1 → XP_038426663.1  LOW QUALITY PROTEIN: histone acetyltransferase KAT2B isoform X1

    UniProtKB/TrEMBL
    A0A8C0RRW4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23190019..23289543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038457130.1 → XP_038313058.1  histone acetyltransferase KAT2B isoform X1

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:740 → 839
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:500 → 839
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:87 → 338
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  2. XM_038457135.1 → XP_038313063.1  histone acetyltransferase KAT2B isoform X6

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:629 → 728
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:389 → 728
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:1 → 227
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  3. XM_038457131.1 → XP_038313059.1  histone acetyltransferase KAT2B isoform X2

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:735 → 834
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:495 → 834
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  4. XM_038457132.1 → XP_038313060.1  histone acetyltransferase KAT2B isoform X3

    UniProtKB/TrEMBL
    A0A8C0RRW4, A0A8I3S1Z4
    Conserved Domains (3) summary
    cd05509
    Location:706 → 805
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:466 → 805
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:24 → 304
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  5. XM_038457133.1 → XP_038313061.1  histone acetyltransferase KAT2B isoform X4

    UniProtKB/TrEMBL
    A0A8C0RRW4
    Conserved Domains (3) summary
    cd05509
    Location:702 → 801
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    COG5076
    Location:462 → 801
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:20 → 300
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain

  6. XM_038457134.1 → XP_038313062.1  histone acetyltransferase KAT2B isoform X5

    UniProtKB/TrEMBL
    A0A8C0TKA3
    Conserved Domains (2) summary
    COG5076
    Location:495 → 660
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    pfam06466
    Location:53 → 333
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
Nucleotide Protein
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