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CTNNB1 catenin beta 1 [ Canis lupus familiaris (dog) ]

Gene ID: 477032, updated on 5-Mar-2024

Summary

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Official Symbol
CTNNB1provided by VGNC
Official Full Name
catenin beta 1provided by VGNC
Primary source
VGNC:VGNC:39700
See related
Ensembl:ENSCAFG00845017609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (10821172..10860317)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (10596271..10609470)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (10790373..10803572)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (10656868..10670063)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (10798400..10811602)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111091974 Neighboring gene uncharacterized LOC106557639 Neighboring gene 28S ribosomal protein S16, mitochondrial-like Neighboring gene uncharacterized LOC111091882 Neighboring gene unc-51 like kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of β-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma. Lean FZ, et al. J Comp Pathol, 2014 May. PMID 24529514
  2. β-Catenin transcriptional activity is minimal in canine osteosarcoma and its targeted inhibition results in minimal changes to cell line behaviour. Piskun CM, et al. Vet Comp Oncol, 2016 Jun. PMID 24256430, Free PMC Article
  3. β-catenin in canine skin: immunohistochemical pattern of expression in normal skin and cutaneous epithelial tumours. Bongiovanni L, et al. J Comp Pathol, 2011 Aug-Oct. PMID 21388636
  4. Characterization of β-catenin expression in canine osteosarcoma. Stein TJ, et al. Vet Comp Oncol, 2011 Mar. PMID 21303455, Free PMC Article
  5. TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of β-catenin in a renal epithelial cell model. Espadas-Álvarez H, et al. J Cell Physiol, 2021 May. PMID 33044004

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of beta-catenin in a renal epithelial cell model.
    Title: TRPV4 activity regulates nuclear Ca(2+) and transcriptional functions of β-catenin in a renal epithelial cell model.
  2. Src- and confinement-dependent FAK activation causes E-cadherin relaxation and beta-catenin activity.
    Title: Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity.
  3. These results indicate that strain-induced Src phosphorylation of beta-catenin and Wnt-dependent beta-catenin stabilization synergize to increase beta-catenin-mediated transcription to levels required for mitosis.
    Title: Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis.
  4. The results show the existence of a softening of the adherens junctional complex in progestagen-dominated stages favoring embryo-maternal interactions and endometrial invasion during canine implantation.
    Title: Immunolocalization of E-cadherin and β-catenin in the cyclic and early pregnant canine endometrium.
  5. Suppression of beta-catenin metabolism, either by RNA interference or a dominant-negative T-cell factor suggested that Wnt signaling is minimally active in canine osteosarcoma and its targeted inhibition is not a relevant therapeutic strategy.
    Title: β-Catenin transcriptional activity is minimal in canine osteosarcoma and its targeted inhibition results in minimal changes to cell line behaviour.
  6. It was concluded that the conducted research did not prove an association between these polymorphisms and canine testicular or ovotesticular XX DSD.
    Title: Polymorphism of the CTNNB1 and FOXL2 Genes is not Associated with Canine XX Testicular/Ovotesticular Disorder of Sex Development.
  7. activation of Yap1 and beta-catenin may represent a master regulator of mechanical strain-induced cell proliferation, and cadherins provide signaling centers required for cellular responses to externally applied force.
    Title: Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry.
  8. As in men, beta-catenin is involved in canine prostatic carcinogenesis, thus further validating the use of this animal model to study human prostatic disease.
    Title: Expression of β-catenin and mesenchymal markers in canine prostatic hyperplasia and carcinoma.
  9. study shows decorin blocks several biological activities mediated by Met signaling axis; these effects were mediated by downregulation of noncanonical beta-catenin levels; Myc was downregulated by decorin; phosphorylation of Myc at threonine 58 was induced
    Title: Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  10. No significant difference in beta-catenin expression or activation between osteosarcoma populations differing in serum ALP concentration.
    Title: Wnt/β-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
catenin beta-1
Names
beta-catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137652.1 → NP_001131124.1  catenin beta-1

    See identical proteins and their annotated locations for NP_001131124.1

    Status: PROVISIONAL

    Source sequence(s)
    FJ268743
    UniProtKB/Swiss-Prot
    B6V8E6
    UniProtKB/TrEMBL
    A0A8C0LI45, A0A8C0TDS9
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    10821172..10860317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038431596.1 → XP_038287524.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B6V8E6
    UniProtKB/TrEMBL
    A0A8C0LI45, A0A8C0TDS9
    Related
    ENSCAFP00845024702.1, ENSCAFT00845031553.1
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  2. XM_038431597.1 → XP_038287525.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B6V8E6
    UniProtKB/TrEMBL
    A0A8C0LI45, A0A8C0TDS9
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  3. XM_038431598.1 → XP_038287526.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    B6V8E6
    UniProtKB/TrEMBL
    A0A8C0LI45, A0A8C0TDS9
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  4. XM_038431599.1 → XP_038287527.1  catenin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TDS9, A0A8I3P3V9, A0A8P0PHX3
    Related
    ENSCAFP00845024497.1, ENSCAFT00845031295.1
    Conserved Domains (4) summary
    smart00185
    Location:343 → 383
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:135 → 424
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:395 → 420
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:576 → 615
    Arm; Armadillo/beta-catenin-like repeat

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    10656868..10670063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    10798400..10811602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    10790373..10803572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    10596271..10609470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6V8E6.1 GenPept UniProtKB/Swiss-Prot:B6V8E6

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