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ITM2B integral membrane protein 2B [ Canis lupus familiaris (dog) ]

Gene ID: 476916, updated on 5-Mar-2024

Summary

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Official Symbol
ITM2Bprovided by VGNC
Official Full Name
integral membrane protein 2Bprovided by VGNC
Primary source
VGNC:VGNC:42150
See related
Ensembl:ENSCAFG00845006529
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 22 NC_051826.1 (3368494..3396449, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 22 NC_006604.4 (3283458..3311398, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 22 NC_049243.1 (3222094..3250064, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 22 NC_049282.1 (3154017..3181970, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 22 NC_049763.1 (3216709..3244525, complement)

Chromosome 22 - NC_051826.1Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor 1 Neighboring gene uncharacterized LOC119865173 Neighboring gene uncharacterized LOC119865172 Neighboring gene uncharacterized LOC111091803 Neighboring gene uncharacterized LOC111091765 Neighboring gene uncharacterized LOC111091763 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of amyloid precursor protein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: integral membrane protein 2B; integral membrane protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051826.1 Reference ROS_Cfam_1.0

    Range
    3368494..3396449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430933.1 → XP_038286861.1  integral membrane protein 2B

    UniProtKB/TrEMBL
    A0A8C0PF88, A0A8I3N078, A0A8P0TLH8
    Related
    ENSCAFP00845009082.1, ENSCAFT00845011629.1
    Conserved Domains (1) summary
    smart01039
    Location:137 → 231
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049282.1 Alternate UMICH_Zoey_3.1

    Range
    3154017..3181970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038506318.1 → XP_038362246.1  integral membrane protein 2B

    Conserved Domains (1) summary
    smart01039
    Location:137 → 231
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049763.1 Alternate UNSW_CanFamBas_1.0

    Range
    3216709..3244525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038633680.1 → XP_038489608.1  LOW QUALITY PROTEIN: integral membrane protein 2B

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049243.1 Alternate UU_Cfam_GSD_1.0

    Range
    3222094..3250064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038569516.1 → XP_038425444.1  integral membrane protein 2B

    UniProtKB/TrEMBL
    A0A8C0PF88, A0A8I3N078, A0A8P0TLH8
    Conserved Domains (1) summary
    smart01039
    Location:137 → 231
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006604.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3283458..3311398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038456911.1 → XP_038312839.1  integral membrane protein 2B

    UniProtKB/TrEMBL
    A0A8C0PF88, A0A8I3N078, A0A8P0TLH8
    Conserved Domains (1) summary
    smart01039
    Location:137 → 231
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
Nucleotide Protein
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