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RB1 RB transcriptional corepressor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 476915, updated on 5-Mar-2024

Summary

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Official Symbol
RB1provided by VGNC
Official Full Name
RB transcriptional corepressor 1provided by VGNC
Primary source
VGNC:VGNC:45389
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 22 NC_051826.1 (3143918..3320581, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 22 NC_006604.4 (3090617..3235458, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 22 NC_049243.1 (3028586..3174226, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 22 NC_049282.1 (2960514..3106149, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 22 NC_049763.1 (3023421..3169707, complement)

Chromosome 22 - NC_051826.1Genomic Context describing neighboring genes Neighboring gene RCC1 and BTB domain containing protein 2 Neighboring gene RB transcriptional corepressor 1 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene uncharacterized LOC119865173 Neighboring gene uncharacterized LOC119865172 Neighboring gene uncharacterized LOC111091803 Neighboring gene integral membrane protein 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dinucleotide repeat polymorphism in the canine retinoblastoma (RB1) gene. Venta PJ, et al. Anim Genet, 1999 Dec. PMID 10612248
  2. Altered expression of p53, but not Rb, is involved in canine prostatic carcinogenesis. Pagliarone S, et al. Res Vet Sci, 2016 Apr. PMID 27033932
  3. Canine invasive transitional cell carcinoma cell lines: in vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Dhawan D, et al. Urol Oncol, 2009 May-Jun. PMID 18562222
  4. RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Batsché E, et al. Mol Cell Biol, 1998 Jul. PMID 9632747, Free PMC Article
  5. Gene-specific universal mammalian sequence-tagged sites: application to the canine genome. Venta PJ, et al. Biochem Genet, 1996 Aug. PMID 8894053

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In all normal samples, p53 was expressed in low number of epithelial cells, while a greater number of positive cells were observed in benign prostatic hyperplasia and prostatic carcinomas. Rb protein was expressed in high number of normal, hyperplastic and neoplastic cells without a statistically significant differences.
    Title: Altered expression of p53, but not Rb, is involved in canine prostatic carcinogenesis.
  2. Data show that canine bladder cancer cell lines expressed several proteins of interest associated with bladder cancer prognosis and progression in humans, including p53, cox-2, and pRb protein.
    Title: Canine invasive transitional cell carcinoma cell lines: in vitro tools to complement a relevant animal model of invasive urinary bladder cancer.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Rb-E2F complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinoblastoma-associated protein; LOW QUALITY PROTEIN: retinoblastoma-associated protein
Names
retinoblastoma 1 (including osteosarcoma)
retinoblastoma protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051826.1 Reference ROS_Cfam_1.0

    Range
    3143918..3320581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038430930.1 → XP_038286858.1  retinoblastoma-associated protein isoform X1

    Conserved Domains (2) summary
    pfam01858
    Location:370 → 570
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:112 → 222
    DUF3452; Domain of unknown function (DUF3452)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049282.1 Alternate UMICH_Zoey_3.1

    Range
    2960514..3106149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038506301.1 → XP_038362229.1  retinoblastoma-associated protein isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049763.1 Alternate UNSW_CanFamBas_1.0

    Range
    3023421..3169707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038634344.1 → XP_038490272.1  retinoblastoma-associated protein isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049243.1 Alternate UU_Cfam_GSD_1.0

    Range
    3028586..3174226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038569496.1 → XP_038425424.1  retinoblastoma-associated protein isoform X4

    UniProtKB/TrEMBL
    A0A8I3PVZ7, A0A8P0SA17

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006604.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3090617..3235458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038456910.1 → XP_038312838.1  LOW QUALITY PROTEIN: retinoblastoma-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A8P0SA17
    Conserved Domains (4) summary
    pfam01858
    Location:369 → 569
    RB_A; Retinoblastoma-associated protein A domain
    pfam08934
    Location:764 → 921
    Rb_C; Rb C-terminal domain
    pfam11934
    Location:111 → 221
    DUF3452; Domain of unknown function (DUF3452)
    cd20599
    Location:641 → 767
    CYCLIN_RB; cyclin box found in retinoblastoma-associated protein (RB) and similar proteins
Nucleotide Protein
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