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CALR calreticulin [ Canis lupus familiaris (dog) ]

Gene ID: 476694, updated on 5-Mar-2024

Summary

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Official Symbol
CALRprovided by VGNC
Official Full Name
calreticulinprovided by VGNC
Primary source
VGNC:VGNC:54585
See related
Ensembl:ENSCAFG00845015220
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CRP55; ERp60; HACBP; Calregulin
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (49768253..49772156, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (49123639..49127542, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (49648459..49652362, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (48979448..48983351, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (49405934..49409839, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene GADD45G interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene synaptonemal complex central element protein 2 Neighboring gene glutaryl-CoA dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. Ihara Y, et al. J Cell Biochem, 2011 Sep. PMID 21557298
  2. Calreticulin expression in neoplastic versus normal dog mammary glands: a cDNA subtraction-based study. Okawa T, et al. Res Vet Sci, 2012 Feb. PMID 21126744
  3. Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures. Srithunyarat T, et al. BMC Res Notes, 2017 Mar 21. PMID 28327184, Free PMC Article
  4. Interaction of calreticulin with protein disulfide isomerase. Baksh S, et al. J Biol Chem, 1995 Dec 29. PMID 8537405

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. No significances in plasma catestatin (CST; chromogranin A 344-364) concentrations were found between before and after morphine administration, and plasma vasostatin (VS; calreticulin N-terminal peptide 120-180) did not differ significantly at any time point.
    Title: Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures.
  2. The mRNA expression level of canine calreticulin was significantly higher in canine mammary gland tumour samples than in nontumour samples.
    Title: Calreticulin expression in neoplastic versus normal dog mammary glands: a cDNA subtraction-based study.
  3. calreticulin regulates cell-substratum adhesion by modulating integrin-associated signaling through altered Ca(2+) homeostasis
    Title: Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calreticulin
Names
Endoplasmic reticulum resident protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    49768253..49772156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428450.1 → XP_038284378.1  calreticulin

    UniProtKB/TrEMBL
    A0A8C0P5H0, A0A8C0QVL8, A0A8I3NM03
    Related
    ENSCAFP00845021381.1, ENSCAFT00845027177.1
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    48979448..48983351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038504094.1 → XP_038360022.1  calreticulin

    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    49405934..49409839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631266.1 → XP_038487194.1  calreticulin

    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    49648459..49652362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567123.1 → XP_038423051.1  calreticulin

    UniProtKB/TrEMBL
    A0A8C0P5H0, A0A8C0QVL8, A0A8I3NM03
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    49123639..49127542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_862217.6 → XP_867310.3  calreticulin

    UniProtKB/TrEMBL
    A0A8C0P5H0, A0A8C0QVL8, A0A8I3NM03
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28490.1 GenPept UniProtKB/Swiss-Prot:P28490

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