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MAP3K4 mitogen-activated protein kinase kinase kinase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 476262, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K4provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 4provided by VGNC
Primary source
VGNC:VGNC:42974
See related
Ensembl:ENSCAFG00845002271
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (49776134..49887469)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (50433855..50545486)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (50145324..50257061)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (49658474..49769746)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (49530210..49640896)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095918 Neighboring gene U2 spliceosomal RNA Neighboring gene plasminogen Neighboring gene uncharacterized LOC119870767 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC111095928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 4
XP_013968519.2
XP_013968521.2
XP_013968524.2
XP_022274370.2
XP_022274374.2
XP_038321751.1
XP_038321752.1
XP_038321753.1
XP_038321754.1
XP_038321755.1
XP_038321756.1
XP_038321757.1
XP_038382426.1
XP_038382427.1
XP_038382428.1
XP_038382429.1
XP_038382430.1
XP_038382431.1
XP_038382432.1
XP_038385291.1
XP_038385490.1
XP_038446718.1
XP_038446719.1
XP_038446720.1
XP_038446721.1
XP_038446722.1
XP_038446723.1
XP_038446724.1
XP_038510512.1
XP_038510513.1
XP_038510514.1
XP_038510515.1
XP_038510516.1
XP_038510517.1
XP_038510518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    49776134..49887469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038654584.1 → XP_038510512.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8I3RQL1, A0A8P0T465
    Related
    ENSCAFP00845003199.1, ENSCAFT00845004002.1
    Conserved Domains (1) summary
    cd06626
    Location:1344 → 1603
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_038654586.1 → XP_038510514.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I3MII6, A0A8I3MP56, A0A8P0T465
    Related
    ENSCAFP00845003215.1, ENSCAFT00845004020.1
    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_038654585.1 → XP_038510513.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1340 → 1599
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_038654588.1 → XP_038510516.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1291 → 1550
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_038654590.1 → XP_038510518.1  mitogen-activated protein kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0PR54, A0A8P0NWW1
    Conserved Domains (1) summary
    cl21453
    Location:1344 → 1417
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038654587.1 → XP_038510515.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Related
    ENSCAFP00845003233.1, ENSCAFT00845004039.1
    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  7. XM_038654589.1 → XP_038510517.1  mitogen-activated protein kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R3T0
    Conserved Domains (1) summary
    cd06626
    Location:1250 → 1509
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    49658474..49769746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465823.1 → XP_038321751.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    Conserved Domains (1) summary
    cd06626
    Location:1342 → 1601
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_038465826.1 → XP_038321754.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    Conserved Domains (1) summary
    cd06626
    Location:1293 → 1552
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_038465824.1 → XP_038321752.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    Conserved Domains (1) summary
    cd06626
    Location:1338 → 1597
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_038465827.1 → XP_038321755.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

    Conserved Domains (1) summary
    cd06626
    Location:1289 → 1548
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_038465829.1 → XP_038321757.1  mitogen-activated protein kinase kinase kinase 4 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:1342 → 1415
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038465825.1 → XP_038321753.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  7. XM_038465828.1 → XP_038321756.1  mitogen-activated protein kinase kinase kinase 4 isoform X6

    Conserved Domains (1) summary
    cd06626
    Location:1250 → 1509
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    49530210..49640896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590790.1 → XP_038446718.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    Conserved Domains (1) summary
    cd06626
    Location:1344 → 1603
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_038590792.1 → XP_038446720.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_038590791.1 → XP_038446719.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    Conserved Domains (1) summary
    cd06626
    Location:1340 → 1599
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_038590794.1 → XP_038446722.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

    Conserved Domains (1) summary
    cd06626
    Location:1291 → 1550
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_038590796.1 → XP_038446724.1  mitogen-activated protein kinase kinase kinase 4 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:1344 → 1417
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038590793.1 → XP_038446721.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  7. XM_038590795.1 → XP_038446723.1  mitogen-activated protein kinase kinase kinase 4 isoform X6

    Conserved Domains (1) summary
    cd06626
    Location:1250 → 1509
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    50145324..50257061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038526498.1 → XP_038382426.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N431, A0A8I3MP56, A0A8P0SPG9, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1342 → 1601
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_038526501.1 → XP_038382429.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MZ01, A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1293 → 1552
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_038526499.1 → XP_038382427.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1338 → 1597
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_038526502.1 → XP_038382430.1  mitogen-activated protein kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1289 → 1548
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_038526504.1 → XP_038382432.1  mitogen-activated protein kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0PR54, A0A8P0NWW1
    Conserved Domains (1) summary
    cl21453
    Location:1342 → 1415
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038526500.1 → XP_038382428.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  7. XM_038526503.1 → XP_038382431.1  mitogen-activated protein kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R3T0
    Conserved Domains (1) summary
    cd06626
    Location:1250 → 1509
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    50433855..50545486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014113044.3 → XP_013968519.2  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N431, A0A8I3MP56, A0A8P0SPG9, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1342 → 1601
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. XM_014113049.3 → XP_013968524.2  mitogen-activated protein kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MZ01, A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1293 → 1552
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_014113046.3 → XP_013968521.2  mitogen-activated protein kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1338 → 1597
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_022418662.2 → XP_022274370.2  mitogen-activated protein kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1289 → 1548
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  5. XM_022418666.2 → XP_022274374.2  mitogen-activated protein kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0PR54, A0A8P0NWW1
    Conserved Domains (1) summary
    cl21453
    Location:1342 → 1415
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038529363.1 → XP_038385291.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I3MP56, A0A8P0T465
    Conserved Domains (1) summary
    cd06626
    Location:1295 → 1554
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  7. XM_038529562.1 → XP_038385490.1  mitogen-activated protein kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0R3T0
    Conserved Domains (1) summary
    cd06626
    Location:1250 → 1509
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
Nucleotide Protein
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