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SMAD4 SMAD family member 4 [ Canis lupus familiaris (dog) ]

Gene ID: 476196, updated on 5-Mar-2024

Summary

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Official Symbol
SMAD4provided by VGNC
Official Full Name
SMAD family member 4provided by VGNC
Primary source
VGNC:VGNC:46521
See related
Ensembl:ENSCAFG00845003229
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
MADH4
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (23767402..23821366, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (24868005..24956178, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (23987158..24041139, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (23833038..23921205, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (23719264..23807404, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870726 Neighboring gene mex-3 RNA binding family member C Neighboring gene uncharacterized LOC111095221 Neighboring gene elaC ribonuclease Z 1 Neighboring gene malic enzyme 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. Zhang XJ, et al. Andrologia, 2011 Aug. PMID 21486406

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 4
Names
SMAD, mothers against DPP homolog 4
mothers against decapentaplegic-like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    23767402..23821366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038654107.1 → XP_038510035.1  mothers against decapentaplegic homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:329 → 550
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. XM_038654108.1 → XP_038510036.1  mothers against decapentaplegic homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:329 → 550
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  3. XM_038654109.1 → XP_038510037.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LBT9, A0A8C0SDJ3, A0A8I3RR80, A0A8P0T534
    Related
    ENSCAFP00845004513.1, ENSCAFT00845005687.1
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    23833038..23921205 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465374.1 → XP_038321302.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. XM_038465372.1 → XP_038321300.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  3. XM_038465373.1 → XP_038321301.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  4. XM_038465375.1 → XP_038321303.1  mothers against decapentaplegic homolog 4 isoform X3

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 483
    MH2; C-terminal Mad Homology 2 (MH2) domain

  5. XM_038465376.1 → XP_038321304.1  mothers against decapentaplegic homolog 4 isoform X4

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 436
    MH2; C-terminal Mad Homology 2 (MH2) domain

RNA

  1. XR_005319814.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    23719264..23807404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590288.1 → XP_038446216.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. XM_038590286.1 → XP_038446214.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  3. XM_038590287.1 → XP_038446215.1  mothers against decapentaplegic homolog 4 isoform X2

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  4. XM_038590289.1 → XP_038446217.1  mothers against decapentaplegic homolog 4 isoform X5

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 483
    MH2; C-terminal Mad Homology 2 (MH2) domain

  5. XM_038590290.1 → XP_038446218.1  mothers against decapentaplegic homolog 4 isoform X6

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 436
    MH2; C-terminal Mad Homology 2 (MH2) domain

RNA

  1. XR_005388056.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    23987158..24041139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038525982.1 → XP_038381910.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LBT9, A0A8C0SDJ3, A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. XM_038525980.1 → XP_038381908.1  mothers against decapentaplegic homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:329 → 550
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  3. XM_038525981.1 → XP_038381909.1  mothers against decapentaplegic homolog 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:329 → 550
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  4. XM_038525983.1 → XP_038381911.1  mothers against decapentaplegic homolog 4 isoform X7

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:329 → 492
    MH2; C-terminal Mad Homology 2 (MH2) domain

  5. XM_038525984.1 → XP_038381912.1  mothers against decapentaplegic homolog 4 isoform X8

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:329 → 445
    MH2; C-terminal Mad Homology 2 (MH2) domain

RNA

  1. XR_005353474.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24868005..24956178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487242.1 → XP_038343170.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LBT9, A0A8C0SDJ3, A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  2. XM_022416898.2 → XP_022272606.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LBT9, A0A8C0SDJ3, A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  3. XM_038487178.1 → XP_038343106.1  mothers against decapentaplegic homolog 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LBT9, A0A8C0SDJ3, A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cd10498
    Location:320 → 541
    MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4

  4. XM_038487377.1 → XP_038343305.1  mothers against decapentaplegic homolog 4 isoform X9

    UniProtKB/TrEMBL
    A0A8I3RR80, A0A8P0T534
    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 483
    MH2; C-terminal Mad Homology 2 (MH2) domain

  5. XM_038487434.1 → XP_038343362.1  mothers against decapentaplegic homolog 4 isoform X10

    Conserved Domains (2) summary
    cd10492
    Location:14 → 138
    MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4
    cl00056
    Location:320 → 436
    MH2; C-terminal Mad Homology 2 (MH2) domain

RNA

  1. XR_005331279.1 RNA Sequence

Nucleotide Protein
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