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Gpo1 Glycerophosphate oxidase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47611, updated on 10-May-2024

Summary

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Official Symbol
Gpo1provided by FlyBase
Official Full Name
Glycerophosphate oxidase 1provided by FlyBase
Primary source
FLYBASE:FBgn0022160
Locus tag
Dmel_CG8256
See related
AllianceGenome:FB:FBgn0022160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1(2) K05713; alpha-GPO; alphaGPO; anon-WO0118547.114; CG 8256; CG18786; CG8256; Dmel\CG8256; Gpo; GPO; Gpo-1; GPO-1; l(2)k05713
Summary
Enables glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in flight behavior and glycerophosphate shuttle. Located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; ectoderm anlage; germ layer; and posterior midgut primordium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
52C8-52C8; 2-75 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15857752..15862755, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11745257..11750260, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tungus Neighboring gene uncharacterized protein Neighboring gene cGAS-like receptor 1 Neighboring gene Rap1 interacting factor 1 Neighboring gene slit Neighboring gene antisense RNA:CR46471 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Segmental aneuploidy as a probe for structural genes in Drosophila: mitochondrial membrane enzymes. O'Brien SJ, et al. Genetics, 1973 Sep. PMID 4202771, Free PMC Article
  2. Micro-spatial population differentiation in activity of glycerol-3-phosphate oxidase (GPO) from mitochondria of Drosophila melanogaster. Ross JL, et al. Genetica, 1991. PMID 1769561
  3. The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants. Carmon A, et al. J Hered, 2010 Mar-Apr. PMID 19995806, Free PMC Article
  4. The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. O'Brien SJ, et al. Biochem Genet, 1972 Oct. PMID 4340553
  5. A genetic and molecular analysis of the alpha glycerophosphate cycle in Drosophila melanogaster. MacIntyre RJ, et al. Isozymes Curr Top Biol Med Res, 1987. PMID 3110096

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
    Title: The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
  2. Gene trees for the GPDH and GPO paralogs indicate that the genes expressed in the flight muscles are evolving very slowly presumably under strong purifying selection whereas the paralogs expressed in the testes are evolving more rapidly.
    Title: The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in flight behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophosphate shuttle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
glycerophosphate oxidase 1
Names
CG8256-PA
CG8256-PB
CG8256-PC
CG8256-PD
Gpo1-PA
Gpo1-PB
Gpo1-PC
Gpo1-PD
alpha glycerophosphate oxidase
alpha glycerophosphate oxidase 1
alpha-Glycerophosphate oxidase
glycerophosphate oxidase
glycerophosphate oxidase-1
lethal (2) k05713
mitochondrial GPD
mitochondrial glycerol-3-phosphate dehydrogenase
NP_001097332.1
NP_611063.1
NP_725495.1
NP_725496.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15857752..15862755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137219.3 → NP_611063.1  glycerophosphate oxidase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K569
    Related
    FBpp0086442
    Conserved Domains (4) summary
    PLN02464
    Location:9 → 594
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:624 → 684
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:624 → 683
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:458 → 583
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

  2. NM_166119.2 → NP_725496.1  glycerophosphate oxidase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725496.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K569
    Related
    FBpp0086443
    Conserved Domains (4) summary
    PLN02464
    Location:9 → 594
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:624 → 684
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:624 → 683
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:458 → 583
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

  3. NM_166118.2 → NP_725495.1  glycerophosphate oxidase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K569
    Related
    FBpp0086444
    Conserved Domains (4) summary
    PLN02464
    Location:9 → 594
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:624 → 684
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:624 → 683
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:458 → 583
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

  4. NM_001103862.2 → NP_001097332.1  glycerophosphate oxidase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K569
    Conserved Domains (4) summary
    PLN02464
    Location:9 → 594
    PLN02464; glycerol-3-phosphate dehydrogenase
    cd00051
    Location:624 → 684
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:624 → 683
    EF-hand_7; EF-hand domain pair
    pfam16901
    Location:458 → 583
    DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K569 Q7K569

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