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PNPLA8 patatin like phospholipase domain containing 8 [ Canis lupus familiaris (dog) ]

Gene ID: 475880, updated on 5-Mar-2024

Summary

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Official Symbol
PNPLA8provided by VGNC
Official Full Name
patatin like phospholipase domain containing 8provided by VGNC
Primary source
VGNC:VGNC:44758
See related
Ensembl:ENSCAFG00845022366
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PNPLA8 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (12406088..12453716)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (11779378..11825993)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (12371185..12418564)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (12223261..12270831)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (12143880..12191247)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152560 Neighboring gene NME/NM23 family member 8 Neighboring gene uncharacterized LOC119864172 Neighboring gene neuronal cell adhesion molecule Neighboring gene laminin subunit beta 4 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia. Abitbol M, et al. Anim Genet, 2022 Oct. PMID 35864734, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia.
    Title: A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calcium-independent phospholipase A2-gamma
XP_005630992.1
XP_022260900.1
XP_038279664.1
XP_038279665.1
XP_038279666.1
XP_038356021.1
XP_038356022.1
XP_038356023.1
XP_038418611.1
XP_038418612.1
XP_038418613.1
XP_038482694.1
XP_038482695.1
XP_038482696.1
XP_533087.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    12406088..12453716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038423736.1 → XP_038279664.1  calcium-independent phospholipase A2-gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBD4, A0A8C0S9W8, A0A8I3PEV9
    Related
    ENSCAFP00845031023.1, ENSCAFT00845039600.1
    Conserved Domains (1) summary
    cd07211
    Location:437 → 743
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  2. XM_038423737.1 → XP_038279665.1  calcium-independent phospholipase A2-gamma isoform X2

    UniProtKB/TrEMBL
    A0A8C0PBD4
    Conserved Domains (1) summary
    cd07211
    Location:336 → 642
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  3. XM_038423738.1 → XP_038279666.1  calcium-independent phospholipase A2-gamma isoform X3

    UniProtKB/TrEMBL
    A0A8I3PEJ7, A0A8P0S9B0
    Conserved Domains (1) summary
    cl11396
    Location:437 → 628
    Patatin_and_cPLA2; Patatins and Phospholipases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    12223261..12270831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500093.1 → XP_038356021.1  calcium-independent phospholipase A2-gamma isoform X1

    Conserved Domains (1) summary
    cd07211
    Location:437 → 743
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  2. XM_038500094.1 → XP_038356022.1  calcium-independent phospholipase A2-gamma isoform X2

    Conserved Domains (1) summary
    cd07211
    Location:336 → 642
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  3. XM_038500095.1 → XP_038356023.1  calcium-independent phospholipase A2-gamma isoform X3

    Conserved Domains (1) summary
    cl11396
    Location:437 → 628
    Patatin_and_cPLA2; Patatins and Phospholipases

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    12143880..12191247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626766.1 → XP_038482694.1  calcium-independent phospholipase A2-gamma isoform X1

    Conserved Domains (1) summary
    cd07211
    Location:437 → 743
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  2. XM_038626767.1 → XP_038482695.1  calcium-independent phospholipase A2-gamma isoform X2

    Conserved Domains (1) summary
    cd07211
    Location:336 → 642
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  3. XM_038626768.1 → XP_038482696.1  calcium-independent phospholipase A2-gamma isoform X3

    Conserved Domains (1) summary
    cl11396
    Location:437 → 628
    Patatin_and_cPLA2; Patatins and Phospholipases

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    12371185..12418564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562683.1 → XP_038418611.1  calcium-independent phospholipase A2-gamma isoform X1

    UniProtKB/TrEMBL
    A0A8C0LK45, A0A8C0PBD4

  2. XM_038562684.1 → XP_038418612.1  calcium-independent phospholipase A2-gamma isoform X2

    UniProtKB/TrEMBL
    A0A8C0PBD4

  3. XM_038562685.1 → XP_038418613.1  calcium-independent phospholipase A2-gamma isoform X3

    UniProtKB/TrEMBL
    A0A8I3PEJ7, A0A8P0S9B0

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    11779378..11825993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005630935.3 → XP_005630992.1  calcium-independent phospholipase A2-gamma isoform X1

    See identical proteins and their annotated locations for XP_005630992.1

    UniProtKB/TrEMBL
    A0A8C0PBD4, A0A8C0S9W8, A0A8I3PEV9
    Conserved Domains (1) summary
    cd07211
    Location:437 → 743
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  2. XM_533087.6 → XP_533087.4  calcium-independent phospholipase A2-gamma isoform X2

    See identical proteins and their annotated locations for XP_533087.4

    UniProtKB/TrEMBL
    A0A8C0PBD4
    Conserved Domains (1) summary
    cd07211
    Location:336 → 642
    Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

  3. XM_022405192.2 → XP_022260900.1  calcium-independent phospholipase A2-gamma isoform X4

    UniProtKB/TrEMBL
    A0A8I3PEJ7, A0A8P0S9B0
    Conserved Domains (1) summary
    cl11396
    Location:437 → 628
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein
Heading Accession and Version

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