U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADAM17 ADAM metallopeptidase domain 17 [ Canis lupus familiaris (dog) ]

Gene ID: 475662, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ADAM17provided by VGNC
Official Full Name
ADAM metallopeptidase domain 17provided by VGNC
Primary source
VGNC:VGNC:37576
See related
Ensembl:ENSCAFG00845024728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 17
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (6687702..6737271, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (6517667..6566403, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (6597002..6645753, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (6580977..6629669, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (6583178..6631850, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene uncharacterized LOC111090413

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing. Sarasa L, et al. Neuroscience, 2010 Dec 29. PMID 20875843

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
TNF-alpha converting enzyme
a disintegrin and metalloproteinase domain 17
snake venom-like protease
NP_001273795.1
NP_001273796.1
NP_001273797.1
XP_038546396.1
XP_038546397.1
XP_038546398.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286866.2 → NP_001273795.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAAUVH010000359
    UniProtKB/TrEMBL
    A0A8C0LWU0, A0A8C0Q8D6, A0A8I3Q5Z6, M1V4E8
    Related
    ENSCAFP00845034679.1, ENSCAFT00845044255.1
    Conserved Domains (4) summary
    smart00050
    Location:480 → 556
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 473
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:52 → 148
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:577 → 637
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  2. NM_001286867.2 → NP_001273796.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    JAAUVH010000359
    UniProtKB/TrEMBL
    M1VKS6
    Conserved Domains (3) summary
    smart00050
    Location:246 → 322
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:1 → 239
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:343 → 404
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  3. NM_001286868.2 → NP_001273797.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon resulting in initiation of translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    JAAUVH010000359
    UniProtKB/TrEMBL
    A0A8I3PUH7, A0A8P0PDW3, M1VRQ7
    Related
    ENSCAFP00845035085.1, ENSCAFT00845044772.1
    Conserved Domains (3) summary
    smart00050
    Location:185 → 261
    DISIN; Homologues of snake disintegrins
    pfam16698
    Location:282 → 343
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
    cl00064
    Location:3 → 178
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    6687702..6737271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690468.1 → XP_038546396.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    M1V4E8
    Conserved Domains (3) summary
    smart00050
    Location:392 → 468
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:131 → 385
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:489 → 550
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  2. XM_038690469.1 → XP_038546397.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    M1VKS6
    Conserved Domains (3) summary
    smart00050
    Location:349 → 425
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:88 → 342
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:446 → 507
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

  3. XM_038690470.1 → XP_038546398.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X3

    UniProtKB/TrEMBL
    A0A8I3PUH7, A0A8P0PDW3, M1VRQ7
    Related
    ENSCAFP00845034940.1, ENSCAFT00845044598.1
    Conserved Domains (3) summary
    smart00050
    Location:185 → 261
    DISIN; Homologues of snake disintegrins
    pfam16698
    Location:282 → 343
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
    cl00064
    Location:3 → 178
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    6580977..6629669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    6583178..6631850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    6597002..6645753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    6517667..6566403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Miscellaneous