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F11 coagulation factor XI [ Canis lupus familiaris (dog) ]

Gene ID: 475623, updated on 22-Jan-2024

Summary

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Official Symbol
F11provided by VGNC
Official Full Name
coagulation factor XIprovided by VGNC
Primary source
VGNC:VGNC:40544
See related
Ensembl:ENSCAFG00845019228
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
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Genomic context

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Location:
chromosome: 16
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (46683089..46700923, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (44956542..44972975, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (45395778..45412243, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (44652096..44668510, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (45264846..45281307, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene melatonin receptor 1A Neighboring gene uncharacterized LOC119874663 Neighboring gene uncharacterized LOC119869610 Neighboring gene kallikrein B1 Neighboring gene cytochrome P450 family 4 subfamily V member 2 Neighboring gene family with sequence similarity 149 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XI
Names
plasma thromboplastin antecedent
NP_001128595.1
XP_038544794.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135123.1 → NP_001128595.1  coagulation factor XI precursor

    See identical proteins and their annotated locations for NP_001128595.1

    Status: PROVISIONAL

    Source sequence(s)
    EU918291
    UniProtKB/TrEMBL
    A0A8C0NKV2, B5LX43
    Related
    ENSCAFP00845026753.1, ENSCAFT00845034175.1
    Conserved Domains (3) summary
    smart00223
    Location:199 → 282
    APPLE; APPLE domain
    smart00020
    Location:386 → 617
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:387 → 617
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    46683089..46700923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038688866.1 → XP_038544794.1  coagulation factor XI isoform X1

    UniProtKB/TrEMBL
    A0A8C0NKK8, A0A8C0NKV2, A0A8I3P9T1
    Related
    ENSCAFP00845026653.1, ENSCAFT00845034051.1
    Conserved Domains (2) summary
    smart00223
    Location:211 → 294
    APPLE; APPLE domain
    cd00190
    Location:399 → 629
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    44652096..44668510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    45264846..45281307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    45395778..45412243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44956542..44972975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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