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IDO1 indoleamine 2,3-dioxygenase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 475574, updated on 5-Mar-2024

Summary

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Official Symbol
IDO1provided by VGNC
Official Full Name
indoleamine 2,3-dioxygenase 1provided by VGNC
Primary source
VGNC:VGNC:41865
See related
Ensembl:ENSCAFG00845009259
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
INDO
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (27218925..27234204, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (25901596..25916857, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (26131508..26146796, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (25516922..25532182, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (26072694..26087946, complement)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene transcriptional and immune response regulator Neighboring gene uncharacterized LOC111090284 Neighboring gene uncharacterized LOC102153319 Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene splicing factor 3B subunit 4-like Neighboring gene A disintegrin and metallopeptidase domain 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. Kathrani A, et al. PLoS One, 2019. PMID 31181125, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. decreased serum tryptophan concentrations in dogs with protein-losing enteropathy is associated with increased intestinal IDO-1 expression.
    Title: Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables indoleamine 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
indoleamine 2,3-dioxygenase 1
Names
indoleamine-pyrrole 2,3 dioxygenase
XP_038353469.1
XP_038415932.1
XP_038479963.1
XP_038545722.1
XP_532793.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    27218925..27234204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038689794.1 → XP_038545722.1  indoleamine 2,3-dioxygenase 1

    UniProtKB/TrEMBL
    A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
    Related
    ENSCAFP00845012750.1, ENSCAFT00845016390.1
    Conserved Domains (1) summary
    pfam01231
    Location:16 → 401
    IDO; Indoleamine 2,3-dioxygenase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    25516922..25532182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497541.1 → XP_038353469.1  indoleamine 2,3-dioxygenase 1

    Conserved Domains (1) summary
    pfam01231
    Location:16 → 401
    IDO; Indoleamine 2,3-dioxygenase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    26072694..26087946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038624035.1 → XP_038479963.1  indoleamine 2,3-dioxygenase 1

    Conserved Domains (1) summary
    pfam01231
    Location:16 → 401
    IDO; Indoleamine 2,3-dioxygenase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    26131508..26146796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038560004.1 → XP_038415932.1  indoleamine 2,3-dioxygenase 1

    UniProtKB/TrEMBL
    A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
    Conserved Domains (1) summary
    pfam01231
    Location:16 → 401
    IDO; Indoleamine 2,3-dioxygenase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25901596..25916857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_532793.7 → XP_532793.1  indoleamine 2,3-dioxygenase 1

    UniProtKB/TrEMBL
    A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
    Conserved Domains (1) summary
    pfam01231
    Location:16 → 401
    IDO; Indoleamine 2,3-dioxygenase
Nucleotide Protein
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