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BRAF B-Raf proto-oncogene, serine/threonine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 475526, updated on 5-Mar-2024

Summary

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Official Symbol
BRAFprovided by VGNC
Official Full Name
B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:38514
See related
Ensembl:ENSCAFG00845031038
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See BRAF in Genome Data Viewer
Location:
chromosome: 16
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (8065738..8237942)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (8989501..9160850)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (7929505..8101841)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (8017140..8188930)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (7861588..8033660)

Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090230 Neighboring gene uncharacterized LOC111090231 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC119877087 Neighboring gene uncharacterized LOC111090232 Neighboring gene uncharacterized LOC111090233 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs. Maeda S, et al. Vet Pathol, 2021 Sep. PMID 33205710
  2. Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer. Cronise KE, et al. Mol Pharmacol, 2019 Jul. PMID 31048548
  3. [Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma]. Aupperle-Lellbach H, et al. Tierarztl Prax Ausg K Kleintiere Heimtiere, 2018 Oct. PMID 30541168
  4. BRAF Mutations in Canine Cancers. Mochizuki H, et al. PLoS One, 2015. PMID 26053201, Free PMC Article
  5. Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas. Shelly S, et al. Mamm Genome, 2005 Mar. PMID 15834638

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
    Title: EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
  2. BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.
    Title: BRAF(V595E) Mutation Associates CCL17 Expression and Regulatory T Cell Recruitment in Urothelial Carcinoma of Dogs.
  3. Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma.
    Title: Aberrant expression of the COX2/PGE(2) axis is induced by activation of the RAF/MEK/ERK pathway in BRAF(V595E) canine urothelial carcinoma.
  4. Studied use of B-Raf proto-oncogene serine/threonine kinase (BRAF) mutational analysis as a tumor marker in canine transitional cell carcinoma.
    Title: [Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].
  5. a single nucleotide T to A transversion at nucleotide 1349 of BRAF occurred in 64 primary tumors of dogs.
    Title: BRAF Mutations in Canine Cancers.
  6. BRAF alternative splicing is differentially regulated in mammals. Exon 9b is present in vertebrates but exon 8b is present only in eutherians.
    Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.
  7. canine oral malignant melanomas do not possess codon 599 BRAF mutations commonly identified in human cutaneous melanomas. This supports the notion that melanomas arising from non-sun-exposed sites exhibit distinct mechanisms of molecular transformation.
    Title: Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase B-raf
Names
B-raf protein
v-raf murine sarcoma viral oncogene homolog B1
XP_038308737.1
XP_038308738.1
XP_038308739.1
XP_038308740.1
XP_038308741.1
XP_038308742.1
XP_038308743.1
XP_038308744.1
XP_038352975.1
XP_038352976.1
XP_038352977.1
XP_038352978.1
XP_038352979.1
XP_038352980.1
XP_038415313.1
XP_038415314.1
XP_038415315.1
XP_038415316.1
XP_038415317.1
XP_038415318.1
XP_038479294.1
XP_038479295.1
XP_038479296.1
XP_038479297.1
XP_038479298.1
XP_038479299.1
XP_038545012.1
XP_038545013.1
XP_038545014.1
XP_038545015.1
XP_038545016.1
XP_038545017.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051820.1 Reference ROS_Cfam_1.0

    Range
    8065738..8237942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038689089.1 → XP_038545017.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0A8C0S060, A0A8I3SCX1, Q698R1
    Related
    ENSCAFP00845043393.1, ENSCAFT00845055177.1
    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  2. XM_038689084.1 → XP_038545012.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  3. XM_038689085.1 → XP_038545013.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    A0A6B9SMP2, Q698R1
    Related
    ENSCAFP00845043390.1, ENSCAFT00845055173.1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 711
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  4. XM_038689086.1 → XP_038545014.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd14062
    Location:459 → 661
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  5. XM_038689087.1 → XP_038545015.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    cl21453
    Location:459 → 616
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038689088.1 → XP_038545016.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/TrEMBL
    A0A8C0L7C0
    Conserved Domains (3) summary
    cd14062
    Location:313 → 559
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cl00040
    Location:80 → 139
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28922
    Location:19 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049276.1 Alternate UMICH_Zoey_3.1

    Range
    8017140..8188930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038497052.1 → XP_038352980.1  serine/threonine-protein kinase B-raf isoform X6

    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  2. XM_038497047.1 → XP_038352975.1  serine/threonine-protein kinase B-raf isoform X1

    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  3. XM_038497048.1 → XP_038352976.1  serine/threonine-protein kinase B-raf isoform X2

    Conserved Domains (3) summary
    cd14062
    Location:459 → 711
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  4. XM_038497049.1 → XP_038352977.1  serine/threonine-protein kinase B-raf isoform X3

    Conserved Domains (3) summary
    cd14062
    Location:459 → 661
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  5. XM_038497050.1 → XP_038352978.1  serine/threonine-protein kinase B-raf isoform X4

    Conserved Domains (3) summary
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    cl21453
    Location:459 → 616
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038497051.1 → XP_038352979.1  serine/threonine-protein kinase B-raf isoform X5

    Conserved Domains (3) summary
    cd14062
    Location:313 → 559
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cl00040
    Location:80 → 139
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28922
    Location:19 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

    Range
    7861588..8033660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623371.1 → XP_038479299.1  serine/threonine-protein kinase B-raf isoform X6

    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  2. XM_038623366.1 → XP_038479294.1  serine/threonine-protein kinase B-raf isoform X1

    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  3. XM_038623367.1 → XP_038479295.1  serine/threonine-protein kinase B-raf isoform X2

    Conserved Domains (3) summary
    cd14062
    Location:459 → 711
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  4. XM_038623368.1 → XP_038479296.1  serine/threonine-protein kinase B-raf isoform X3

    Conserved Domains (3) summary
    cd14062
    Location:459 → 661
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  5. XM_038623369.1 → XP_038479297.1  serine/threonine-protein kinase B-raf isoform X4

    Conserved Domains (3) summary
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    cl21453
    Location:459 → 616
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038623370.1 → XP_038479298.1  serine/threonine-protein kinase B-raf isoform X5

    Conserved Domains (3) summary
    cd14062
    Location:313 → 559
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cl00040
    Location:80 → 139
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28922
    Location:19 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

    Range
    7929505..8101841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559390.1 → XP_038415318.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0A8C0S060, A0A8I3SCX1, Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  2. XM_038559385.1 → XP_038415313.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  3. XM_038559386.1 → XP_038415314.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    A0A6B9SMP2, Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 711
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  4. XM_038559387.1 → XP_038415315.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd14062
    Location:459 → 661
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  5. XM_038559388.1 → XP_038415316.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    cl21453
    Location:459 → 616
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038559389.1 → XP_038415317.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/TrEMBL
    A0A8C0L7C0
    Conserved Domains (3) summary
    cd14062
    Location:313 → 559
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cl00040
    Location:80 → 139
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28922
    Location:19 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    8989501..9160850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038452815.1 → XP_038308743.1  serine/threonine-protein kinase B-raf isoform X6

    UniProtKB/TrEMBL
    A0A8C0S060, A0A8I3SCX1, Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  2. XM_038452809.1 → XP_038308737.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  3. XM_038452811.1 → XP_038308739.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    A0A6B9SMP2, Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 711
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  4. XM_038452816.1 → XP_038308744.1  serine/threonine-protein kinase B-raf isoform X8

    UniProtKB/TrEMBL
    Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:499 → 751
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  5. XM_038452810.1 → XP_038308738.1  serine/threonine-protein kinase B-raf isoform X7

    UniProtKB/TrEMBL
    Q698R1
    Conserved Domains (3) summary
    cd14062
    Location:459 → 705
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  6. XM_038452812.1 → XP_038308740.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd14062
    Location:459 → 661
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

  7. XM_038452813.1 → XP_038308741.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0A8C0MIU3
    Conserved Domains (3) summary
    cd17134
    Location:150 → 228
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
    cd20871
    Location:226 → 285
    C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    cl21453
    Location:459 → 616
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038452814.1 → XP_038308742.1  serine/threonine-protein kinase B-raf isoform X5

    UniProtKB/TrEMBL
    A0A8C0L7C0
    Conserved Domains (3) summary
    cd14062
    Location:313 → 559
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    cl00040
    Location:80 → 139
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl28922
    Location:19 → 82
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
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