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TDO2 tryptophan 2,3-dioxygenase [ Canis lupus familiaris (dog) ]

Gene ID: 475476, updated on 5-Mar-2024

Summary

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Official Symbol
TDO2provided by VGNC
Official Full Name
tryptophan 2,3-dioxygenaseprovided by VGNC
Primary source
VGNC:VGNC:47217
See related
Ensembl:ENSCAFG00845010812
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (54113213..54132114)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (53741684..53760577)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (53790005..53808893)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (53366630..53385412)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (53475754..53494647)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene trifunctional enzyme subunit beta, mitochondrial-like Neighboring gene acid sensing ion channel subunit family member 5 Neighboring gene cathepsin O Neighboring gene uncharacterized LOC111090110

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tryptophan catabolic process to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 2,3-dioxygenase A; tryptophan 2,3-dioxygenase
XP_038352624.1
XP_038415016.1
XP_038478957.1
XP_038544629.1
XP_532700.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    54113213..54132114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038688701.1 → XP_038544629.1  tryptophan 2,3-dioxygenase

    UniProtKB/TrEMBL
    A0A8C0JMT8, A0A8C0JQJ7, A0A8C0RE89, A0A8I3NIH8
    Related
    ENSCAFP00845014904.1, ENSCAFT00845019078.1
    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    53366630..53385412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038496696.1 → XP_038352624.1  tryptophan 2,3-dioxygenase

    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    53475754..53494647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623029.1 → XP_038478957.1  tryptophan 2,3-dioxygenase

    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    53790005..53808893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559088.1 → XP_038415016.1  tryptophan 2,3-dioxygenase

    UniProtKB/TrEMBL
    A0A8C0JMT8, A0A8C0JQJ7, A0A8C0RE89, A0A8I3NIH8
    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53741684..53760577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_532700.7 → XP_532700.2  tryptophan 2,3-dioxygenase

    UniProtKB/TrEMBL
    A0A8C0JMT8, A0A8C0JQJ7, A0A8C0RE89, A0A8I3NIH8
    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase
Nucleotide Protein
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