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FGA fibrinogen alpha chain [ Canis lupus familiaris (dog) ]

Gene ID: 475473, updated on 5-Mar-2024

Summary

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Official Symbol
FGAprovided by VGNC
Official Full Name
fibrinogen alpha chainprovided by VGNC
Primary source
VGNC:VGNC:54205
See related
Ensembl:ENSCAFG00845009752
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (52924743..52933990, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (52584628..52591483, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (52601176..52608068, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (52179682..52188900, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (52283995..52293478, complement)

Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene pleiotropic regulator 1 Neighboring gene fibrinogen beta chain Neighboring gene fibrinogen gamma chain Neighboring gene ribosomal L1 domain-containing protein 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds. Mischke R, et al. Genes (Basel), 2021 Jul 13. PMID 34356081, Free PMC Article
  2. Diversity of primary structures of the carboxy-terminal regions of mammalian fibrinogen A alpha-chains. Characterization of the partial nucleotide and deduced amino acid sequences in five mammalian species; rhesus monkey, pig, dog, mouse and Syrian hamster. Murakawa M, et al. Thromb Haemost, 1993 Apr 1. PMID 8497848

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds.
    Title: An FGA Frameshift Variant Associated with Afibrinogenemia in Dachshunds.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in blood coagulation, common pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of fibrinogen complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibrinogen alpha chain
Names
carboxy-terminal region
fibrinogen A-alpha-chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051819.1 Reference ROS_Cfam_1.0

    Range
    52924743..52933990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038688683.1 → XP_038544611.1  fibrinogen alpha chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0MTI9, A0A8C0SEX7, A0A8I3NBI4, A0A8P0NAN3
    Related
    ENSCAFP00845013388.1, ENSCAFT00845017181.1
    Conserved Domains (4) summary
    cd00087
    Location:671 → 904
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:50 → 190
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:495 → 555
    Fibrinogen_aC; Fibrinogen alpha C domain
    cl11081
    Location:264 → 426
    dermokine

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049275.1 Alternate UMICH_Zoey_3.1

    Range
    52179682..52188900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038496680.1 → XP_038352608.1  fibrinogen alpha chain isoform X1

    Conserved Domains (4) summary
    cd00087
    Location:671 → 904
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    pfam08702
    Location:50 → 190
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:495 → 555
    Fibrinogen_aC; Fibrinogen alpha C domain
    cl11081
    Location:264 → 426
    dermokine

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

    Range
    52283995..52293478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038623009.1 → XP_038478937.1  fibrinogen alpha chain isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

    Range
    52601176..52608068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038559074.1 → XP_038415002.1  fibrinogen alpha chain isoform X2

    UniProtKB/TrEMBL
    A0A8I3RXA2, A0A8P0SRG0
    Conserved Domains (3) summary
    pfam08702
    Location:50 → 190
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:480 → 540
    Fibrinogen_aC; Fibrinogen alpha C domain
    cl11081
    Location:264 → 411
    dermokine

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    52584628..52591483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_532697.7 → XP_532697.3  fibrinogen alpha chain isoform X3

    UniProtKB/TrEMBL
    A0A8I3RXA2, A0A8P0SRG0
    Conserved Domains (3) summary
    pfam08702
    Location:50 → 190
    Fib_alpha; Fibrinogen alpha/beta chain family
    pfam12160
    Location:480 → 540
    Fibrinogen_aC; Fibrinogen alpha C domain
    cl11081
    Location:264 → 411
    dermokine
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68213.1 GenPept UniProtKB/Swiss-Prot:P68213

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