PRDX1 peroxiredoxin 1 [Canis lupus familiaris (dog)] - Gene

Summary

Gene symbol: PRDX1
Gene description: peroxiredoxin 1
See related: Ensembl:ENSCAFG00845022593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (14988879..15010844)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (14959792..14976803)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (14930831..14947857)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (14790828..14808277)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (14858579..14875829)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prdx1 (e-PCR), detects polymorphism
- UniSTS:259380

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables thioredoxin peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leukocyte activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-1

NP_001239094.1

EC 1.11.1.24

EC 1.11.1.7

XP_038543111.1

EC 1.11.1.24

EC 1.11.1.7

XP_038543112.1

EC 1.11.1.24

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252165.1 → NP_001239094.1 peroxiredoxin-1

See identical proteins and their annotated locations for NP_001239094.1

Status: VALIDATED

Source sequence(s)

CO672929, DN370732

UniProtKB/TrEMBL

A0A8C0KVJ8, A0A8C0SYI9, A0A8I3S380, A0A8P0N7B2, A0A8P0T4S3

Related

ENSCAFP00845031296.1, ENSCAFT00845039966.1

Conserved Domains (1) summary

cd03015
Location:8 → 180

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051819.1 Reference ROS_Cfam_1.0

Range

14988879..15010844

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038687184.1 → XP_038543112.1 peroxiredoxin-1 isoform X2

UniProtKB/TrEMBL

A0A8C0KVJ8, A0A8C0SYI9, A0A8I3S380, A0A8P0N7B2, A0A8P0T4S3

Conserved Domains (1) summary

cd03015
Location:8 → 180

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
XM_038687183.1 → XP_038543111.1 peroxiredoxin-1 isoform X1

UniProtKB/TrEMBL

A0A8I3PG86, A0A8I3S380, A0A8P0N7B2

Related

ENSCAFP00845031350.1, ENSCAFT00845040036.1

Conserved Domains (1) summary

cd03015
Location:17 → 189

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...