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HDAC2 histone deacetylase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 475035, updated on 5-Mar-2024

Summary

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Official Symbol
HDAC2provided by VGNC
Official Full Name
histone deacetylase 2provided by VGNC
Primary source
VGNC:VGNC:49101
See related
Ensembl:ENSCAFG00845020776
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (70933049..70962557, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (69799259..69828714, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (70454633..70484021, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (70285352..70314769, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (70123758..70153135, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106559557 Neighboring gene myristoylated alanine rich protein kinase C substrate Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 5 Neighboring gene uncharacterized LOC111098407 Neighboring gene uncharacterized LOC111098196

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Housley DJ, et al. Genomics, 2004 Aug. PMID 15233990

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 2
XP_013973700.2
XP_038348608.1
XP_038348609.1
XP_038348610.1
XP_038410927.1
XP_038410928.1
XP_038410929.1
XP_038474797.1
XP_038474798.1
XP_038474799.1
XP_038534730.1
XP_038534734.1
XP_038540351.1
XP_038540352.1
XP_038540353.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    70933049..70962557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038684423.1 → XP_038540351.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAX5
    Conserved Domains (2) summary
    COG4547
    Location:407 → 500
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:39 → 395
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_038684424.1 → XP_038540352.1  histone deacetylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MAX5, A0A8C0MG29, A0A8I3S1X7
    Related
    ENSCAFP00845028668.1, ENSCAFT00845036630.1
    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

  3. XM_038684425.1 → XP_038540353.1  histone deacetylase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MAX5
    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    70285352..70314769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492680.1 → XP_038348608.1  histone deacetylase 2 isoform X1

  2. XM_038492681.1 → XP_038348609.1  histone deacetylase 2 isoform X2

    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

  3. XM_038492682.1 → XP_038348610.1  histone deacetylase 2 isoform X3

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    70123758..70153135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618869.1 → XP_038474797.1  histone deacetylase 2 isoform X1

    Conserved Domains (2) summary
    COG4547
    Location:407 → 500
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:39 → 395
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_038618870.1 → XP_038474798.1  histone deacetylase 2 isoform X2

    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

  3. XM_038618871.1 → XP_038474799.1  histone deacetylase 2 isoform X3

    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    70454633..70484021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554999.1 → XP_038410927.1  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAX5

  2. XM_038555000.1 → XP_038410928.1  histone deacetylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MAX5, A0A8C0MG29, A0A8I3S1X7
    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

  3. XM_038555001.1 → XP_038410929.1  histone deacetylase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MAX5
    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    69799259..69828714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014118225.3 → XP_013973700.2  histone deacetylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAX5
    Conserved Domains (2) summary
    pfam14797
    Location:414 → 508
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    cl17011
    Location:39 → 395
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_038678802.1 → XP_038534730.1  histone deacetylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MAX5, A0A8C0MG29, A0A8I3S1X7
    Conserved Domains (2) summary
    cd10011
    Location:9 → 374
    HDAC2; Histone deacetylase 2 (HDAC2)
    COG4547
    Location:386 → 479
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]

  3. XM_038678806.1 → XP_038534734.1  histone deacetylase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MAX5
    Conserved Domains (2) summary
    COG4547
    Location:356 → 449
    CobT2; Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphorib... [Coenzyme transport and metabolism]
    cl17011
    Location:1 → 344
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
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