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FYN FYN proto-oncogene, Src family tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 475032, updated on 11-Apr-2024

Summary

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Official Symbol
FYNprovided by VGNC
Official Full Name
FYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:41027
See related
Ensembl:ENSCAFG00845017640
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (68986784..69198525, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (67924675..68136151, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (68510644..68722405, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (68338226..68549311, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (68184783..68396306, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119874234 Neighboring gene uncharacterized LOC119874235 Neighboring gene TRAF3 interacting protein 2 Neighboring gene uncharacterized LOC111098400 Neighboring gene uncharacterized LOC111098401 Neighboring gene uncharacterized LOC106559589

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase Fyn
Names
FYN oncogene related to SRC, FGR, YES
XP_005627776.1
XP_038348587.1
XP_038348589.1
XP_038348590.1
XP_038410908.1
XP_038410909.1
XP_038410910.1
XP_038474775.1
XP_038474776.1
XP_038474777.1
XP_038529477.1
XP_038540327.1
XP_038540328.1
XP_038540329.1
XP_854467.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    68986784..69198525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038684401.1 → XP_038540329.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2
    Related
    ENSCAFP00845024839.1, ENSCAFT00845031738.1
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_038684399.1 → XP_038540327.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Related
    ENSCAFP00845024737.1, ENSCAFT00845031600.1
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_038684400.1 → XP_038540328.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    68338226..68549311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492662.1 → XP_038348590.1  tyrosine-protein kinase Fyn isoform X2

    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_038492659.1 → XP_038348587.1  tyrosine-protein kinase Fyn isoform X1

    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_038492661.1 → XP_038348589.1  tyrosine-protein kinase Fyn isoform X1

    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    68184783..68396306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618849.1 → XP_038474777.1  tyrosine-protein kinase Fyn isoform X2

    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_038618847.1 → XP_038474775.1  tyrosine-protein kinase Fyn isoform X1

    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_038618848.1 → XP_038474776.1  tyrosine-protein kinase Fyn isoform X1

    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    68510644..68722405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554982.1 → XP_038410910.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_038554980.1 → XP_038410908.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_038554981.1 → XP_038410909.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    67924675..68136151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005627719.3 → XP_005627776.1  tyrosine-protein kinase Fyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0MFP4, A0A8C0S435, A0A8I3P3X1, A0A8I3S2Y2
    Conserved Domains (3) summary
    cd10368
    Location:145 → 245
    SH2_Src_Fyn; Src homology 2 (SH2) domain found in Fyn
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:258 → 531
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  2. XM_849374.5 → XP_854467.1  tyrosine-protein kinase Fyn isoform X1

    See identical proteins and their annotated locations for XP_854467.1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn

  3. XM_038673549.1 → XP_038529477.1  tyrosine-protein kinase Fyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0L2L5, A0A8C0S435, A0A8I3NYU1, A0A8I3P3X1, A0A8P0P4J3
    Conserved Domains (3) summary
    cd10418
    Location:145 → 245
    SH2_Src_Fyn_isoform_a_like; Src homology 2 (SH2) domain found in Fyn isoform a like proteins
    cd12006
    Location:85 → 140
    SH3_Fyn_Yrk; Src homology 3 domain of Fyn and Yrk Protein Tyrosine Kinases
    cd05070
    Location:261 → 534
    PTKc_Fyn; Catalytic domain of the Protein Tyrosine Kinase, Fyn
Nucleotide Protein
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