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CDKN1A cyclin dependent kinase inhibitor 1A [ Canis lupus familiaris (dog) ]

Gene ID: 474890, updated on 5-Mar-2024

Summary

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Official Symbol
CDKN1Aprovided by VGNC
Official Full Name
cyclin dependent kinase inhibitor 1Aprovided by VGNC
Primary source
VGNC:VGNC:39068
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
p21
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (6095734..6103965)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (5765839..5774065)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (5928229..5936457)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (5750615..5758848)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (5829928..5838160)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098236 Neighboring gene uncharacterized LOC119874264 Neighboring gene RAB44, member RAS oncogene family Neighboring gene galanin receptor 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis. Kortum AJ, et al. J Vet Intern Med, 2018 Sep. PMID 30133945, Free PMC Article
  2. Breed-related expression patterns of Ki67, γH2AX, and p21 during ageing in the canine liver. Hardwick LJA, et al. Vet Res Commun, 2021 Feb. PMID 33301127, Free PMC Article
  3. Phenotype-rescue of cyclin-dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer. DeInnocentes P, et al. J Cell Biochem, 2009 Feb 15. PMID 19130492
  4. Immunohistochemical detection of p27 and p21 proteins in canine hair follicle and epidermal neoplasms. Inoue M, et al. J Vet Med Sci, 2006 Aug. PMID 16953075
  5. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Stewart-Ornstein J, et al. Cell Rep, 2016 Feb 23. PMID 26876176, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Breed-related expression patterns of Ki67, gammaH2AX, and p21 during ageing in the canine liver.
    Title: Breed-related expression patterns of Ki67, γH2AX, and p21 during ageing in the canine liver.
  2. It was concluded that marked p21 immunopositivity in dogs with chronic hepatitis might be indicative of widespread hepatocellular senescence.
    Title: Hepatocyte expression and prognostic importance of senescence marker p21 in liver histopathology samples from dogs with chronic hepatitis.
  3. Dynamics of CDKN1A in single cells has been defined defined by an endogenous fluorescent tagging.
    Title: Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit.
  4. p21 plays a key role in mechanisms used by PTEN-deficient tumors to escape chemotherapy
    Title: Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.
  5. This study found that nuclear p27 acts as a cyclin-dependent kinase (CDK) inhibitor in canine skin neoplasms and nuclear p21 expression is involved in the induction of epithelial differentiation and seems to be unrelated to CDK inhibition.
    Title: Immunohistochemical detection of p27 and p21 proteins in canine hair follicle and epidermal neoplasms.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase inhibitor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    6095734..6103965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683339.1 → XP_038539267.1  cyclin-dependent kinase inhibitor 1

    UniProtKB/TrEMBL
    A0A7I8E886, A0A8C0K0B2, Q683K8
    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor

  2. XM_038683340.1 → XP_038539268.1  cyclin-dependent kinase inhibitor 1

    UniProtKB/TrEMBL
    A0A7I8E886, A0A8C0K0B2, Q683K8
    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    5750615..5758848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491658.1 → XP_038347586.1  cyclin-dependent kinase inhibitor 1

    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor

  2. XM_038491659.1 → XP_038347587.1  cyclin-dependent kinase inhibitor 1

    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    5829928..5838160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038617745.1 → XP_038473673.1  cyclin-dependent kinase inhibitor 1

  2. XM_038617746.1 → XP_038473674.1  cyclin-dependent kinase inhibitor 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    5928229..5936457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038553885.1 → XP_038409813.1  cyclin-dependent kinase inhibitor 1

    UniProtKB/TrEMBL
    Q683K8

  2. XM_038553886.1 → XP_038409814.1  cyclin-dependent kinase inhibitor 1

    UniProtKB/TrEMBL
    Q683K8

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    5765839..5774065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_532125.7 → XP_532125.3  cyclin-dependent kinase inhibitor 1

    See identical proteins and their annotated locations for XP_532125.3

    UniProtKB/TrEMBL
    A0A7I8E886, A0A8C0K0B2, Q683K8
    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor

  2. XM_005627279.4 → XP_005627336.1  cyclin-dependent kinase inhibitor 1

    See identical proteins and their annotated locations for XP_005627336.1

    UniProtKB/TrEMBL
    A0A7I8E886, A0A8C0K0B2, Q683K8
    Conserved Domains (1) summary
    pfam02234
    Location:21 → 66
    CDI; Cyclin-dependent kinase inhibitor
Nucleotide Protein
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