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SPOCK1 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 [ Canis lupus familiaris (dog) ]

Gene ID: 474688, updated on 5-Mar-2024

Summary

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Official Symbol
SPOCK1provided by VGNC
Official Full Name
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1provided by VGNC
Primary source
VGNC:VGNC:59043
See related
Ensembl:ENSCAFG00845016123
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (25550901..26073758, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (23482135..23980859, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (24771888..25267226, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (24288279..24783213, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (24106169..24605094, complement)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda constant 1-like Neighboring gene G2/mitotic-specific cyclin-B1-like Neighboring gene 40S ribosomal protein S24-like Neighboring gene uncharacterized LOC111097932 Neighboring gene elongation factor 1-alpha 1-like Neighboring gene kelch like family member 3 Neighboring gene microRNA mir-874

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
testican-1
Names
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    25550901..26073758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038681596.1 → XP_038537524.1  testican-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Related
    ENSCAFP00845022676.1, ENSCAFT00845028815.1
    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312 → 373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:245 → 276
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:198 → 309
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  2. XM_038681595.1 → XP_038537523.1  testican-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Conserved Domains (4) summary
    smart00280
    Location:140 → 181
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:315 → 376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:248 → 279
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:201 → 312
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  3. XM_038681597.1 → XP_038537525.1  testican-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K4G0
    Related
    ENSCAFP00845022725.1, ENSCAFT00845028882.1
    Conserved Domains (3) summary
    smart00280
    Location:65 → 106
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:240 → 301
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16237
    Location:126 → 237
    EFh_SPARC_TICN1; EF-hand, extracellular calcium-binding (EC) motif, found in testican-1 (TICN1)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    24288279..24783213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038490162.1 → XP_038346090.1  testican-1 isoform X2

    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312 → 373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:245 → 276
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:198 → 309
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  2. XM_038490161.1 → XP_038346089.1  testican-1 isoform X1

    Conserved Domains (4) summary
    smart00280
    Location:140 → 181
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:315 → 376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:248 → 279
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:201 → 312
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  3. XM_038490163.1 → XP_038346091.1  testican-1 isoform X3

    Conserved Domains (3) summary
    smart00280
    Location:65 → 106
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:240 → 301
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16237
    Location:126 → 237
    EFh_SPARC_TICN1; EF-hand, extracellular calcium-binding (EC) motif, found in testican-1 (TICN1)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    24106169..24605094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038616108.1 → XP_038472036.1  testican-1 isoform X2

    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312 → 373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:245 → 276
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:198 → 309
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  2. XM_038616107.1 → XP_038472035.1  testican-1 isoform X1

    Conserved Domains (4) summary
    smart00280
    Location:140 → 181
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:315 → 376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:248 → 279
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:201 → 312
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  3. XM_038616109.1 → XP_038472037.1  testican-1 isoform X3

    Conserved Domains (3) summary
    smart00280
    Location:65 → 106
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:240 → 301
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16237
    Location:126 → 237
    EFh_SPARC_TICN1; EF-hand, extracellular calcium-binding (EC) motif, found in testican-1 (TICN1)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    24771888..25267226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038552240.1 → XP_038408168.1  testican-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312 → 373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:245 → 276
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:198 → 309
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  2. XM_038552239.1 → XP_038408167.1  testican-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Conserved Domains (4) summary
    smart00280
    Location:140 → 181
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:315 → 376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:248 → 279
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:201 → 312
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  3. XM_038552241.1 → XP_038408169.1  testican-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K4G0
    Conserved Domains (3) summary
    smart00280
    Location:65 → 106
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:240 → 301
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16237
    Location:126 → 237
    EFh_SPARC_TICN1; EF-hand, extracellular calcium-binding (EC) motif, found in testican-1 (TICN1)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23482135..23980859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663356.1 → XP_038519284.1  testican-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Conserved Domains (4) summary
    smart00280
    Location:137 → 178
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:312 → 373
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:245 → 276
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:198 → 309
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  2. XM_038663351.1 → XP_038519279.1  testican-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I3P1Y3
    Conserved Domains (4) summary
    smart00280
    Location:140 → 181
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:315 → 376
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:248 → 279
    EFh_SPARC_EC; EF-hand motif [structural motif]
    cl25349
    Location:201 → 312
    EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

  3. XM_038663364.1 → XP_038519292.1  testican-1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0K4G0
    Conserved Domains (3) summary
    smart00280
    Location:65 → 106
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:240 → 301
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16237
    Location:126 → 237
    EFh_SPARC_TICN1; EF-hand, extracellular calcium-binding (EC) motif, found in testican-1 (TICN1)
Nucleotide Protein
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