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EPAS1 endothelial PAS domain protein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 474578, updated on 5-Mar-2024

Summary

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Official Symbol
EPAS1provided by VGNC
Official Full Name
endothelial PAS domain protein 1provided by VGNC
Primary source
VGNC:VGNC:40391
See related
Ensembl:ENSCAFG00845027702
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See EPAS1 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (49422114..49508080)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (48405643..48491569)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (49603605..49689524)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (49131051..49216377)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (49421043..49506595)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097735 Neighboring gene uncharacterized LOC111097736 Neighboring gene uncharacterized LOC119873669 Neighboring gene uncharacterized LOC111097737 Neighboring gene transmembrane protein 247

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids. Wang MS, et al. Mol Biol Evol, 2020 Sep 1. PMID 32384152
  2. Genome-wide identification and analysis of basic helix-loop-helix domains in dog, Canis lupus familiaris. Wang XH, et al. Mol Genet Genomics, 2015 Apr. PMID 25403511

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids.
    Title: Ancient Hybridization with an Unknown Population Facilitated High-Altitude Adaptation of Canids.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
endothelial PAS domain-containing protein 1; LOW QUALITY PROTEIN: endothelial PAS domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    49422114..49508080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680486.1 → XP_038536414.1  endothelial PAS domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0LRG2, A0A8C0NAE9, A0A8C0YRR8
    Related
    ENSCAFP00845038415.1, ENSCAFT00845048970.1
    Conserved Domains (5) summary
    smart00091
    Location:86 → 147
    PAS; PAS domain
    cd19728
    Location:9 → 74
    bHLH-PAS_HIF2a_PASD2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 2-alpha (HIF2a) and similar proteins
    pfam08778
    Location:833 → 868
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:517 → 549
    HIF-1; Hypoxia-inducible factor-1
    pfam14598
    Location:244 → 346
    PAS_11; PAS domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    49131051..49216377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038489201.1 → XP_038345129.1  LOW QUALITY PROTEIN: endothelial PAS domain-containing protein 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    49421043..49506595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615102.1 → XP_038471030.1  endothelial PAS domain-containing protein 1

    Conserved Domains (5) summary
    smart00091
    Location:86 → 147
    PAS; PAS domain
    cd19728
    Location:9 → 74
    bHLH-PAS_HIF2a_PASD2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 2-alpha (HIF2a) and similar proteins
    pfam08778
    Location:833 → 868
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:517 → 549
    HIF-1; Hypoxia-inducible factor-1
    pfam14598
    Location:244 → 346
    PAS_11; PAS domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    49603605..49689524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551203.1 → XP_038407131.1  endothelial PAS domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0LRG2, A0A8C0NAE9, A0A8C0YRR8
    Conserved Domains (5) summary
    smart00091
    Location:86 → 147
    PAS; PAS domain
    cd19728
    Location:9 → 74
    bHLH-PAS_HIF2a_PASD2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 2-alpha (HIF2a) and similar proteins
    pfam08778
    Location:833 → 868
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:517 → 549
    HIF-1; Hypoxia-inducible factor-1
    pfam14598
    Location:244 → 346
    PAS_11; PAS domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    48405643..48491569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022424681.2 → XP_022280389.2  endothelial PAS domain-containing protein 1

    UniProtKB/TrEMBL
    A0A8C0LRG2, A0A8C0NAE9, A0A8C0YRR8
    Conserved Domains (5) summary
    smart00091
    Location:86 → 147
    PAS; PAS domain
    cd19728
    Location:9 → 74
    bHLH-PAS_HIF2a_PASD2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 2-alpha (HIF2a) and similar proteins
    pfam08778
    Location:833 → 868
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam11413
    Location:517 → 549
    HIF-1; Hypoxia-inducible factor-1
    pfam14598
    Location:244 → 346
    PAS_11; PAS domain
Nucleotide Protein
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