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EPS8 EGFR pathway substrate 8, signaling adaptor [ Pan troglodytes (chimpanzee) ]

Gene ID: 473379, updated on 3-Apr-2024

Summary

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Official Symbol
EPS8provided by VGNC
Official Full Name
EGFR pathway substrate 8, signaling adaptorprovided by VGNC
Primary source
VGNC:VGNC:5366
Locus tag
CK820_G0019158
See related
Ensembl:ENSPTRG00000004733
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (22751355..22922170, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (21419779..21590238, complement)

Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC129136514 Neighboring gene tRNA N(3)-methylcytidine methyltransferase METTL2-like Neighboring gene protein tyrosine phosphatase receptor type O Neighboring gene U6 spliceosomal RNA Neighboring gene small ribosomal subunit protein uS7m-like Neighboring gene uncharacterized LOC107967469 Neighboring gene serine/threonine kinase receptor associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ruffle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor kinase substrate 8
Names
epidermal growth factor receptor pathway substrate 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    22751355..22922170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_528750.8 → XP_528750.3  epidermal growth factor receptor kinase substrate 8 isoform X2

    See identical proteins and their annotated locations for XP_528750.3

    UniProtKB/TrEMBL
    A0A2I3RZT9, A0A2J8QQ12, A0A6D2Y240, H2Q5J3
    Conserved Domains (3) summary
    cd09540
    Location:720 → 784
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:535 → 588
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  2. XM_054664109.2 → XP_054520084.1  epidermal growth factor receptor kinase substrate 8 isoform X1

  3. XM_003313524.7 → XP_003313572.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    See identical proteins and their annotated locations for XP_003313572.1

    UniProtKB/TrEMBL
    A0A2I3RZT9, A0A2J8QQ12, A0A6D2Y240, H2Q5J3
    Conserved Domains (3) summary
    cd09540
    Location:720 → 784
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:535 → 588
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

  4. XM_009424921.5 → XP_009423196.1  epidermal growth factor receptor kinase substrate 8 isoform X2

    See identical proteins and their annotated locations for XP_009423196.1

    UniProtKB/TrEMBL
    A0A2I3RZT9, A0A2J8QQ12, A0A6D2Y240, H2Q5J3
    Related
    ENSPTRP00000008080.4
    Conserved Domains (3) summary
    cd09540
    Location:720 → 784
    SAM_EPS8-like; SAM domain of EPS8-like subfamily
    cd11764
    Location:535 → 588
    SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
    cd01210
    Location:64 → 191
    PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain
Nucleotide Protein
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