LYN LYN proto-oncogene, Src family tyrosine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: LYNprovided by VGNC
Official Full Name: LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:8181
Locus tag: CK820_G0032856
See related: Ensembl:ENSPTRG00000020263
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	7	NC_072405.2 (64473936..64611851)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	8	NC_072406.1 (69393903..69529496)

Chromosome 7 - NC_072405.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

RH18289 (e-PCR)
- UniSTS:56576

D8S1516 (e-PCR)
- UniSTS:57176

D8S1828 (e-PCR)
- UniSTS:16478

RH69081 (e-PCR)
- UniSTS:39826

SHGC-58186 (e-PCR)
- UniSTS:9365

D8S1930 (e-PCR)
- UniSTS:55474

LYN_1415 (e-PCR)
- UniSTS:277459

GDB:386774 (e-PCR)
- UniSTS:157151

RH48206 (e-PCR)
- UniSTS:13029

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Fc receptor mediated stimulatory signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dendritic cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of mast cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron projection development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in platelet degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of dendritic cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of B cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tolerance induction to self antigen	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Lyn

Names: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

XP_003311845.1

EC 2.7.10.2

XP_016814989.3

EC 2.7.10.2

XP_528143.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

64473936..64611851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016959500.4 → XP_016814989.3 tyrosine-protein kinase Lyn isoform X1
XM_003311797.6 → XP_003311845.1 tyrosine-protein kinase Lyn isoform X3

See identical proteins and their annotated locations for XP_003311845.1

UniProtKB/TrEMBL

A0A2J8L510, A0A8I3B183, K7A5D4, K7AHF5

Conserved Domains (3) summary

cd10364
Location:104 → 204

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:46 → 101

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:218 → 489

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
XM_528143.6 → XP_528143.2 tyrosine-protein kinase Lyn isoform X2

See identical proteins and their annotated locations for XP_528143.2

UniProtKB/TrEMBL

A0A2J8L508, A0A6D2X4B7, H2R453

Related

ENSPTRP00000046608.4

Conserved Domains (3) summary

cd10364
Location:125 → 225

SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn

cd12004
Location:67 → 122

SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase

cd05072
Location:239 → 510

PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn