IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: IKBKBprovided by VGNC
Official Full Name: inhibitor of nuclear factor kappa B kinase subunit betaprovided by VGNC
Primary source: VGNC:VGNC:14635
Locus tag: CK820_G0013031
See related: Ensembl:ENSPTRG00000020202
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	7	NC_072405.2 (50572985..50634063)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	8	NC_072406.1 (54152990..54213785)

Chromosome 7 - NC_072405.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH104595 (e-PCR)
- UniSTS:99861

RH75091 (e-PCR)
- UniSTS:86861

STS-N21119 (e-PCR)
- UniSTS:25813

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables IkappaB kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

XP_016814901.2

EC 2.7.11.10

XP_016814902.1

EC 2.7.11.10

XP_016814905.2

EC 2.7.11.10

XP_024200913.1

EC 2.7.11.10

XP_054512656.1

EC 2.7.11.10

XP_054512657.1

EC 2.7.11.10

XP_054512658.1

EC 2.7.11.10

XP_054512660.1

EC 2.7.11.10

XP_063672376.1

EC 2.7.11.10

XP_063672377.1

EC 2.7.11.10

XP_063672379.1

EC 2.7.11.10

XP_063672380.1

EC 2.7.11.10

XP_063672381.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

50572985..50634063

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024345145.3 → XP_024200913.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

UniProtKB/TrEMBL

A0A2J8N7A7, A0A6D2XP95, K7C5Z9, K7CMD5

Conserved Domains (2) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam12179
Location:708 → 742

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
XM_016959413.4 → XP_016814902.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

UniProtKB/TrEMBL

K7CNM9
XM_016959416.4 → XP_016814905.2 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3
XM_054656681.2 → XP_054512656.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4
XM_054656682.2 → XP_054512657.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5
XM_054656683.2 → XP_054512658.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X6

UniProtKB/TrEMBL

A0A2I3T3F9, A0A2J8N797, A0A6D2VYX9
XM_063816309.1 → XP_063672379.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X7
XM_054656685.2 → XP_054512660.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8
XM_063816311.1 → XP_063672381.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X10
XM_063816310.1 → XP_063672380.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9
XM_016959412.4 → XP_016814901.2 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1
XM_063816306.1 → XP_063672376.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

UniProtKB/TrEMBL

A0A2J8N7A7, A0A6D2XP95, K7CMD5
XM_063816307.1 → XP_063672377.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5