DUSP1 dual specificity phosphatase 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: DUSP1provided by VGNC
Official Full Name: dual specificity phosphatase 1provided by VGNC
Primary source: VGNC:VGNC:11934
Locus tag: CK820_G0025752
See related: Ensembl:ENSPTRG00000017534
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	4	NC_072402.2 (170431804..170435010, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	5	NC_072403.1 (170454076..170457239, complement)

Chromosome 4 - NC_072402.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:30977

D8S2279 (e-PCR)
- UniSTS:473907

G06586 (e-PCR)
- UniSTS:51801

DUSP4 (e-PCR)
- UniSTS:519308

GDB:371394 (e-PCR)
- UniSTS:156846

DUSP1_317 (e-PCR)
- UniSTS:277175

WI-22759 (e-PCR)
- UniSTS:38105

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables MAP kinase tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables MAP kinase tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in endoderm formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity protein phosphatase 1

XP_527120.2

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

170431804..170435010 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_527120.8 → XP_527120.2 dual specificity protein phosphatase 1

See identical proteins and their annotated locations for XP_527120.2

UniProtKB/TrEMBL

A0A2J8LY04, A0A6D2WJQ9, H2QS06

Related

ENSPTRP00000029948.2

Conserved Domains (2) summary

cd01446
Location:7 → 136

DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

cd14638
Location:174 → 324

DSP_DUSP1; dual specificity phosphatase domain of dual specificity protein phosphatase 1