HTR1A 5-hydroxytryptamine receptor 1A [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HTR1Aprovided by VGNC
Official Full Name: 5-hydroxytryptamine receptor 1Aprovided by VGNC
Primary source: VGNC:VGNC:8624
Locus tag: CK820_G0034305
See related: Ensembl:ENSPTRG00000016918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Also known as: 5-HT1A; 5-HT-1A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	4	NC_072402.2 (50667698..50668966)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	5	NC_072403.1 (51083086..51084354)

Chromosome 4 - NC_072402.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pro248Gln polymorphism located in the third intracellular loop of the receptor is associated with a reduction in anxiety, decreased rates of male agonistic behavior, and an increase in socio-positive behavior
Title: Serotonin Receptor 1A Variation Is Associated with Anxiety and Agonistic Behavior in Chimpanzees.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481605

RH70818 (e-PCR)
- UniSTS:27760

HTR1A (e-PCR)
- UniSTS:479890

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gs	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1A

Names: 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; Serotonin receptor 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135622.1 → NP_001129094.1 5-hydroxytryptamine receptor 1A

See identical proteins and their annotated locations for NP_001129094.1

Status: PROVISIONAL

Source sequence(s)

AB041404

UniProtKB/Swiss-Prot

Q9N298

UniProtKB/TrEMBL

A0A2J8L1D3

Related

ENSPTRP00000028964.5, ENSPTRT00000031362.5

Conserved Domains (2) summary

pfam00001
Location:53 → 400

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:48 → 169

7tm_4; Olfactory receptor