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dup double parked [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47121, updated on 4-Apr-2024

Summary

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Official Symbol
dupprovided by FlyBase
Official Full Name
double parkedprovided by FlyBase
Primary source
FLYBASE:FBgn0000996
Locus tag
Dmel_CG8171
See related
AllianceGenome:FB:FBgn0000996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
19k; anon-WO0257455.31; cdt1; Cdt1; CDT1; cdt1/dup; CDT1/DUP; CG8171; Dmel\CG8171; Dup; DUP; DUP/CDT1; fs(2)51Fa; fs(2)ltoPA77; fs(2)PA77; l(2)51Ec; l(2)k03308
Summary
Predicted to enable DNA binding activity and DNA polymerase binding activity. Involved in DNA endoreduplication; DNA replication checkpoint signaling; and glial cell growth. Located in cytoplasm; nucleus; and replication fork. Is expressed in optic lobe forming neuroblast; ovariole; and wing disc. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See dup in Genome Data Viewer
Location:
51F11-51F11; 2-74 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15376619..15380988, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11264124..11268493, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene SR Protein Kinase Neighboring gene long non-coding RNA:CR45020 Neighboring gene Stac-like Neighboring gene Metchnikowin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective tracking of template DNA strands after induction of mitosis with unreplicated genomes (MUGs) in Drosophila S2 cells. Drpic D, et al. Chromosome Res, 2013 May. PMID 23681663
  2. Preferential re-replication of Drosophila heterochromatin in the absence of geminin. Ding Q, et al. PLoS Genet, 2010 Sep 9. PMID 20838463, Free PMC Article
  3. Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers. Windner SE, et al. Dev Cell, 2019 Apr 8. PMID 30905770, Free PMC Article
  4. Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility. Sloan RS, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722696
  5. Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase. Lee HO, et al. Mol Biol Cell, 2010 Nov 1. PMID 20826610, Free PMC Article

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2
    Title: Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.
  2. In cycling cells, Dup destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup levels to prevent pre-replicative complex reformation when Dup degradation fails.
    Title: Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chorion-containing eggshell formation HMP PubMed 
involved_in eggshell chorion gene amplification TAS
Traceable Author Statement
more info
 PubMed 
involved_in glial cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in replication fork IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
double parked
Names
CG8171-PA
CG8171-PB
double park
double-parked
doubleparked
dup-PA
dup-PB
female sterile(2)51Fa
lethal(2)51Ec
speckled

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15376619..15380988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080139.5 → NP_524878.1  double parked, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524878.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVY2
    Related
    FBpp0086519
    Conserved Domains (2) summary
    cd08767
    Location:610 → 735
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
    pfam08839
    Location:318 → 500
    CDT1; DNA replication factor CDT1 like

  2. NM_001299522.1 → NP_001286451.1  double parked, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVY2
    Conserved Domains (2) summary
    cd08767
    Location:610 → 735
    Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
    pfam08839
    Location:318 → 500
    CDT1; DNA replication factor CDT1 like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVY2 Q7JVY2

Gene LinkOut

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