U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Pan troglodytes (chimpanzee) ]

Gene ID: 471079, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PIK3CBprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaprovided by VGNC
Primary source
VGNC:VGNC:2512
Locus tag
CK820_G0030090
See related
Ensembl:ENSPTRG00000015452
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (141867398..142049517, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (141776766..141958886, complement)

Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene extended synaptotagmin 3 Neighboring gene centrosomal protein 70 Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene elongation factor 1-alpha 1-like Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene forkhead box L2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Names
phosphoinositide-3-kinase, catalytic, beta polypeptide

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    141867398..142049517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016942047.3 → XP_016797536.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJC8, A0A6D2XVS3, H2QNG6, K7DEK7
    Related
    ENSPTRP00000068259.1
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

  2. XM_016942048.3 → XP_016797537.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

    UniProtKB/TrEMBL
    H2QNG6
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:515 → 685
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:689 → 1050
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

  3. XM_063806265.1 → XP_063662335.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2

  4. XM_003950204.5 → XP_003950253.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJC8, A0A6D2XVS3, H2QNG6, K7DEK7
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

  5. XM_054681091.2 → XP_054537066.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJC8, A0A6D2XVS3, K7DEK7

  6. XM_063806264.1 → XP_063662334.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1

    UniProtKB/TrEMBL
    A0A2J8QJC8, A0A6D2XVS3, K7DEK7
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous