CYP2D6 cytochrome P450 family 2 subfamily D member 6 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CYP2D6provided by VGNC
Official Full Name: cytochrome P450 family 2 subfamily D member 6provided by VGNC
Primary source: VGNC:VGNC:57895
Locus tag: CK820_G0027493
See related: Ensembl:ENSPTRG00000042031
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
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Genomic context

Location:: chromosome: 22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	23	NC_086016.1 (44122676..44127085, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	22	NC_072420.1 (37155072..37159451, complement)

Chromosome 23 - NC_086016.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

GDB:632777 (e-PCR)
- UniSTS:158488

GDB:632780 (e-PCR)
- UniSTS:158489

GDB:632785 (e-PCR)
- UniSTS:158490

STS-M33189 (e-PCR)
- UniSTS:10271

NoName (e-PCR)
- UniSTS:486996

GDB:270292 (e-PCR)
- UniSTS:156348

NoName (e-PCR)
- UniSTS:482281

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in xenobiotic metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cytochrome P450 2D6

Names: CYPIID6; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450-DB1; debrisoquine 4-hydroxylase

NP_001035712.1

EC 1.14.14.1

XP_063663630.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040622.1 → NP_001035712.1 cytochrome P450 2D6

See identical proteins and their annotated locations for NP_001035712.1

Status: PROVISIONAL

Source sequence(s)

DQ282164

UniProtKB/Swiss-Prot

Q2XNC8

UniProtKB/TrEMBL

A0A2J8LMX8, H2QLT8

Conserved Domains (1) summary

pfam00067
Location:58 → 493

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_086016.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

44122676..44127085 complement

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GenBank, FASTA, Sequence Viewer (Graphics)