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NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 [ Homo sapiens (human) ]

Gene ID: 4701, updated on 4-Jan-2025

Summary

Official Symbol
NDUFA7provided by HGNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit A7provided by HGNC
Primary source
HGNC:HGNC:7691
See related
Ensembl:ENSG00000267855 MIM:602139; AllianceGenome:HGNC:7691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B14.5a; CI-B14.5a
Summary
This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in heart (RPKM 24.4), kidney (RPKM 16.8) and 25 other tissues See more
Orthologs
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Genomic context

See NDUFA7 in Genome Data Viewer
Location:
19p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8308595..8321375, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8295117..8307894, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8373479..8386259, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ceramide synthase 4 Neighboring gene uncharacterized LOC107985282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13910 Neighboring gene MPRA-validated peak3333 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8368800-8369366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372005-8372745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372746-8373485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8373541-8374070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8376825-8377427 Neighboring gene CD320 molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8380680-8381486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8384379-8385346 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:8385347-8386314 and GRCh37_chr19:8386315-8387282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8387283-8388248 Neighboring gene ribosomal protein S28 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10019 Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8405154-8405654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8407589-8408380 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial inner membrane  
located_in mitochondrion PubMed 
located_in mitochondrion  
part_of respiratory chain complex I  
part_of respiratory chain complex I PubMed 
part_of respiratory chain complex I PubMed 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NADH-ubiquinone oxidoreductase subunit B14.5a
complex I B14.5a subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028213.2 RefSeqGene

    Range
    5022..15113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005001.5NP_004992.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

    See identical proteins and their annotated locations for NP_004992.2

    Status: REVIEWED

    Source sequence(s)
    AC010323, BC003102
    Consensus CDS
    CCDS42492.1
    UniProtKB/Swiss-Prot
    O95182
    UniProtKB/TrEMBL
    Q6IB89
    Related
    ENSP00000301457.1, ENST00000301457.3
    Conserved Domains (1) summary
    pfam07347
    Location:5102
    CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

RNA

  1. NR_135539.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010323, BC003102, CR975510

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    8308595..8321375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    8295117..8307894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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