CHRM3 cholinergic receptor muscarinic 3 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CHRM3provided by VGNC
Official Full Name: cholinergic receptor muscarinic 3provided by VGNC
Primary source: VGNC:VGNC:8317
Locus tag: CK820_G0023247
See related: Ensembl:ENSPTRG00000002155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	1	NC_072398.2 (9273170..9515571, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	1	NC_072398.1 (221528447..222050168)

Chromosome 1 - NC_072398.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AL009667 (e-PCR)
- UniSTS:20237

CHRM3 (e-PCR)
- UniSTS:253965

D1S1817E (e-PCR)
- UniSTS:82211

SHGC-143172 (e-PCR)
- UniSTS:171818

AL009465 (e-PCR)
- UniSTS:54845

CHRM3_4570 (e-PCR)
- UniSTS:463972

SHGC-142291 (e-PCR)
- UniSTS:171367

G59665 (e-PCR)
- UniSTS:136819

WI-10464 (e-PCR)
- UniSTS:17781

WIAF-1659 (e-PCR)
- UniSTS:69246

SHGC-144279 (e-PCR)
- UniSTS:174221

D1S2381 (e-PCR)
- UniSTS:55701

AL009307 (e-PCR)
- UniSTS:19617

SHGC-76586 (e-PCR)
- UniSTS:57518

SHGC-83993 (e-PCR)
- UniSTS:104624

SHGC-76588 (e-PCR)
- UniSTS:63158

SHGC-79693 (e-PCR)
- UniSTS:102072

AL034024 (e-PCR)
- UniSTS:93645

G62753 (e-PCR)
- UniSTS:139730

G16250 (e-PCR)
- UniSTS:66267

SHGC-76591 (e-PCR)
- UniSTS:14817

CHRM3 (e-PCR)
- UniSTS:479727

AFMA072XA5 (e-PCR)
- UniSTS:70648

AL009400 (e-PCR)
- UniSTS:24575

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables G protein-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in saliva secretion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: muscarinic acetylcholine receptor M3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135621.1 → NP_001129093.1 muscarinic acetylcholine receptor M3

See identical proteins and their annotated locations for NP_001129093.1

Status: PROVISIONAL

Source sequence(s)

AB041396

UniProtKB/Swiss-Prot

Q9N2A4

Related

ENSPTRP00000003643.5, ENSPTRT00000003942.5

Conserved Domains (2) summary

pfam00001
Location:85 → 266

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 209

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072398.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

9273170..9515571 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009441692.5 → XP_009439967.2 muscarinic acetylcholine receptor M3 isoform X1

UniProtKB/TrEMBL

A0A2J8M701, A0A6D2W180, H2Q1E6

Conserved Domains (3) summary

cd14964
Location:487 → 512

7tm_GPCRs; TM helix 6 [structural motif]

cd15299
Location:66 → 270

7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors

cl28897
Location:484 → 564

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_016928280.4 → XP_016783769.1 muscarinic acetylcholine receptor M3 isoform X1

UniProtKB/TrEMBL

A0A2J8M701, A0A6D2W180, H2Q1E6

Conserved Domains (3) summary

cd14964
Location:487 → 512

7tm_GPCRs; TM helix 6 [structural motif]

cd15299
Location:66 → 270

7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors

cl28897
Location:484 → 564

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily