SMAD4 SMAD family member 4 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: SMAD4provided by VGNC
Official Full Name: SMAD family member 4provided by VGNC
Primary source: VGNC:VGNC:13288
Locus tag: CK820_G0011466
See related: Ensembl:ENSPTRG00000010028
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 18

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	17	NC_072415.2 (61089844..61145157)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	18	NC_072416.1 (60070802..60125470)

Chromosome 17 - NC_072415.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

WI-11075 (e-PCR)
- UniSTS:79113

D8S2279 (e-PCR)
- UniSTS:473907

RH66749 (e-PCR)
- UniSTS:67183

AF010230 (e-PCR)
- UniSTS:105082

PMC86557P1 (e-PCR)
- UniSTS:273533

RH46461 (e-PCR)
- UniSTS:15242

RH75869 (e-PCR)
- UniSTS:88461

SHGC-56739 (e-PCR)
- UniSTS:9636

D18S1110 (e-PCR)
- UniSTS:70066

RH44980 (e-PCR)
- UniSTS:49355

MADH4_174 (e-PCR)
- UniSTS:277461

D18S903E (e-PCR)
- UniSTS:150513

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables I-SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of heteromeric SMAD protein complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: mothers against decapentaplegic homolog 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

61089844..61145157

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054671788.2 → XP_054527763.1 mothers against decapentaplegic homolog 4 isoform X1

UniProtKB/TrEMBL

A0A2J8NE34, A0A6D2X8J1, H2QEJ6
XM_001155601.8 → XP_001155601.1 mothers against decapentaplegic homolog 4 isoform X1

See identical proteins and their annotated locations for XP_001155601.1

UniProtKB/TrEMBL

A0A2I3TIB9, A0A2J8NE34, A0A6D2X8J1, H2QEJ6

Related

ENSPTRP00000017047.3

Conserved Domains (2) summary

cd10492
Location:14 → 138

MH1_SMAD_4; N-terminal Mad Homology 1 (MH1) domain in SMAD4

cd10498
Location:320 → 541

MH2_SMAD_4; C-terminal Mad Homology 2 (MH2) domain in SMAD4
XM_063795713.1 → XP_063651783.1 mothers against decapentaplegic homolog 4 isoform X2