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MYC MYC proto-oncogene, bHLH transcription factor [ Pan troglodytes (chimpanzee) ]

Gene ID: 464393, updated on 29-Mar-2024

Summary

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Gene symbol
MYC
Gene description
MYC proto-oncogene, bHLH transcription factor
Locus tag
CK820_G0002327
See related
Ensembl:ENSPTRG00000020581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 7 NC_072405.2 (138018838..138023202)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 8 NC_072406.1 (142612791..142617154)

Chromosome 7 - NC_072405.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100615671 Neighboring gene POU class 5 homeobox 1B Neighboring gene uncharacterized LOC129135886 Neighboring gene uncharacterized LOC134810917 Neighboring gene collagen alpha-1(VII) chain-like Neighboring gene microRNA mir-1204

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and nucleotide sequence of the chimpanzee c-myc gene. Argaut C, et al. Gene, 1991 Jan 15. PMID 1999286
  2. The effects of sequence length and oligonucleotide mismatches on 5' exonuclease assay efficiency. Smith S, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384613, Free PMC Article
  3. An empirical test for branch-specific positive selection. Nickel GC, et al. Genetics, 2008 Aug. PMID 18689901, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myc proto-oncogene protein
Names
proto-oncogene c-Myc
transcription factor p64
v-myc avian myelocytomatosis viral oncogene homolog
v-myc myelocytomatosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142794.1 → NP_001136266.1  myc proto-oncogene protein

    Status: VALIDATED

    Source sequence(s)
    M38057
    UniProtKB/Swiss-Prot
    A2T708, P23583, Q8MJ74
    UniProtKB/TrEMBL
    A0A2J8PNT9
    Related
    ENSPTRP00000075568.1, ENSPTRT00000089249.1
    Conserved Domains (3) summary
    cd00083
    Location:367 → 426
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:21 → 360
    Myc_N; Myc amino-terminal region
    pfam02344
    Location:423 → 453
    Myc-LZ; Myc leucine zipper domain

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    138018838..138023202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23583.2 GenPept UniProtKB/Swiss-Prot:P23583

Gene LinkOut

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