SQLE squalene epoxidase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: SQLEprovided by VGNC
Official Full Name: squalene epoxidaseprovided by VGNC
Primary source: VGNC:VGNC:789
Locus tag: CK820_G0002291
See related: Ensembl:ENSPTRG00000020572
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	7	NC_072405.2 (135328503..135352390)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	8	NC_072406.1 (139922320..139946197)

Chromosome 7 - NC_072405.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

D8S1682 (e-PCR)
- UniSTS:154172

D8S1067 (e-PCR)
- UniSTS:30331

RH48389 (e-PCR)
- UniSTS:39811

A004A38 (e-PCR)
- UniSTS:11141

RH48094 (e-PCR)
- UniSTS:54956

RH15879 (e-PCR)
- UniSTS:28606

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables squalene monooxygenase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: squalene monooxygenase

XP_009454171.1

EC 1.14.14.17

XP_009454172.1

EC 1.14.14.17

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072405.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

135328503..135352390

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009455896.5 → XP_009454171.1 squalene monooxygenase isoform X1

See identical proteins and their annotated locations for XP_009454171.1

UniProtKB/TrEMBL

A0A2I3T6Q1, A0A2J8PNQ9, A0A6D2VWZ7, H2QWP8

Related

ENSPTRP00000035180.3

Conserved Domains (2) summary

cl21454
Location:277 → 548

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

cl27552
Location:122 → 427

FAD_binding_3; FAD binding domain
XM_009455897.5 → XP_009454172.1 squalene monooxygenase isoform X2

UniProtKB/TrEMBL

A0A2J8PNQ7

Related

ENSPTRP00000084867.1

Conserved Domains (3) summary

COG0654
Location:67 → 441

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

pfam08491
Location:219 → 490

SE; Squalene epoxidase

cl21454
Location:68 → 117

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins