BRAF B-Raf proto-oncogene, serine/threonine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: BRAFprovided by VGNC
Official Full Name: B-Raf proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source: VGNC:VGNC:14003
Locus tag: CK820_G0013978
See related: Ensembl:ENSPTRG00000019769 Ensembl:ENSPTRG00000051563
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	6	NC_072404.2 (156081153..156279125, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	7	NC_072405.1 (150154324..150352237, complement)

Chromosome 6 - NC_072404.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRAF alternative splicing is differentially regulated in rodent and primates. Exon 9b is present in vertebrates but exon 8b is present only in eutherians.
Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.

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Pathways from PubChem

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General gene information

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Markers

SHGC-35884 (e-PCR)
- UniSTS:18946

SHGC-79572 (e-PCR)
- UniSTS:103692

D7S2260 (e-PCR)
- UniSTS:153613

SHGC-83405 (e-PCR)
- UniSTS:101909

RH98519 (e-PCR)
- UniSTS:90929

SHGC-79328 (e-PCR)
- UniSTS:103236

GDB:1318226 (e-PCR)
- UniSTS:20310

GDB:1318374 (e-PCR)
- UniSTS:27484

STS-T28237 (e-PCR)
- UniSTS:26491

D7S2227 (e-PCR)
- UniSTS:65428

D7S1672 (e-PCR)
- UniSTS:62114

RH122643 (e-PCR)
- UniSTS:135088

Braf (e-PCR), detects polymorphism
- UniSTS:259512

WI-17864 (e-PCR)
- UniSTS:55019

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase B-raf

Names: v-raf murine sarcoma viral oncogene homolog B1

XP_009452635.3

EC 2.7.11.1

XP_016800946.3

EC 2.7.11.1

XP_054512296.1

EC 2.7.11.1

XP_054512298.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

156081153..156279125 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009454360.5 → XP_009452635.3 serine/threonine-protein kinase B-raf isoform X2
XM_016945457.4 → XP_016800946.3 serine/threonine-protein kinase B-raf isoform X1

UniProtKB/TrEMBL

K7CLW3
XM_054656323.2 → XP_054512298.1 serine/threonine-protein kinase B-raf isoform X4
XM_054656321.2 → XP_054512296.1 serine/threonine-protein kinase B-raf isoform X3