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MET MET proto-oncogene, receptor tyrosine kinase [ Pan troglodytes (chimpanzee) ]

Gene ID: 463671, updated on 11-Apr-2024

Summary

Official Symbol
METprovided by VGNC
Official Full Name
MET proto-oncogene, receptor tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:4426
Locus tag
CK820_G0011823
See related
Ensembl:ENSPTRG00000019614
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
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Genomic context

Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (132057964..132184182)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (126109526..126235429)

Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104007375 Neighboring gene caveolin 1 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC129135567 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables hepatocyte growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
PubMed 
part_of semaphorin receptor complex IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor receptor
Names
HGF receptor
HGF/SF receptor
SF receptor
met proto-oncogene (hepatocyte growth factor receptor)
met proto-oncogene tyrosine kinase
proto-oncogene c-Met
scatter factor receptor
tyrosine-protein kinase Met
NP_001129302.1
XP_009452300.1
XP_016812328.1
XP_016812329.1
XP_063669919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135830.1NP_001129302.1  hepatocyte growth factor receptor precursor

    See identical proteins and their annotated locations for NP_001129302.1

    Status: PROVISIONAL

    Source sequence(s)
    DP000016
    UniProtKB/Swiss-Prot
    Q2QLF1
    UniProtKB/TrEMBL
    A0A2I3T1S4, A0A2J8QXH3, A0A663DES5, K7C095
    Conserved Domains (7) summary
    cd11278
    Location:25516
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:519561
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:838934
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:657740
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563656
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:742837
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10821343
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    132057964..132184182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_016956840.4XP_016812329.1  hepatocyte growth factor receptor isoform X3

    UniProtKB/TrEMBL
    A0A2I3T1S4, A0A2J8QXG8, A0A2K6I2H3, A0A6D2W744
    Related
    ENSPTRP00000057112.3
    Conserved Domains (7) summary
    cd11278
    Location:25516
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:519561
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:856952
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:657740
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563656
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:11001361
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    cl15674
    Location:742855
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. XM_063813849.1XP_063669919.1  hepatocyte growth factor receptor isoform X4

  3. XM_016956839.4XP_016812328.1  hepatocyte growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A2I3T1S4
  4. XM_009454025.5XP_009452300.1  hepatocyte growth factor receptor isoform X2

    See identical proteins and their annotated locations for XP_009452300.1

    UniProtKB/TrEMBL
    A0A2I3T1S4, K7DGW4
    Related
    ENSPTRP00000083162.1
    Conserved Domains (7) summary
    cd11278
    Location:44535
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:538580
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:857953
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:676759
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:582675
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:761856
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:11011362
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron