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PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [ Pan troglodytes (chimpanzee) ]

Gene ID: 463649, updated on 3-Apr-2024

Summary

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Official Symbol
PIK3CGprovided by VGNC
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by VGNC
Primary source
VGNC:VGNC:4468
Locus tag
CK820_G0011926
See related
Ensembl:ENSPTRG00000019573
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (122240842..122284182)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (116292681..116335986)

Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 71 like Neighboring gene uncharacterized LOC129135586 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene HMG-box transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Names
phosphoinositide-3-kinase, catalytic, gamma polypeptide
XP_001162884.1
XP_001162956.1
XP_063671595.1
XP_519303.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    122240842..122284182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_519303.9 → XP_519303.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for XP_519303.2

    UniProtKB/TrEMBL
    A0A2J8QY32, A0A6D2Y2J7, H2R358
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

  2. XM_001162956.8 → XP_001162956.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for XP_001162956.1

    UniProtKB/TrEMBL
    A0A2J8QY32, A0A6D2Y2J7, H2R358
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

  3. XM_001162884.8 → XP_001162884.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    See identical proteins and their annotated locations for XP_001162884.1

    UniProtKB/TrEMBL
    A0A2J8QY32, A0A6D2Y2J7, H2R358
    Related
    ENSPTRP00000044953.4
    Conserved Domains (4) summary
    cd08399
    Location:350 → 527
    C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)
    smart00144
    Location:203 → 312
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:549 → 725
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd00894
    Location:729 → 1095
    PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

  4. XM_063815525.1 → XP_063671595.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

    UniProtKB/TrEMBL
    A0A2J8QY32, A0A6D2Y2J7, H2R358
Nucleotide Protein
Heading Accession and Version

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