HGF hepatocyte growth factor [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HGFprovided by VGNC
Official Full Name: hepatocyte growth factorprovided by VGNC
Primary source: VGNC:VGNC:7392
Locus tag: CK820_G0029054
See related: Ensembl:ENSPTRG00000019349
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	6	NC_072404.2 (91048117..91120100, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	7	NC_072405.1 (87395288..87466714, complement)

Chromosome 6 - NC_072404.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

RH47062 (e-PCR)
- UniSTS:75781

SHGC-31157 (e-PCR)
- UniSTS:24590

STS-AA015815 (e-PCR)
- UniSTS:77839

D7S804 (e-PCR), detects polymorphism
- UniSTS:10017

SHGC-84463 (e-PCR)
- UniSTS:104756

D7S804 (e-PCR), detects polymorphism
- UniSTS:473181

Hgf (e-PCR), detects polymorphism
- UniSTS:256371

Hgf (e-PCR), detects polymorphism
- UniSTS:143341

Hgf (e-PCR), detects polymorphism
- UniSTS:143342

D7S804 (e-PCR), detects polymorphism
- UniSTS:83193

D7S2748 (e-PCR)
- UniSTS:69631

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor

Names: hepatocyte growth factor (hepapoietin A; scatter factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

91048117..91120100 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_519174.9 → XP_519174.2 hepatocyte growth factor isoform X3

See identical proteins and their annotated locations for XP_519174.2

UniProtKB/TrEMBL

A0A2I3S5X5, A0A2J8LGA9, A0A6D2XWI6, H2QUU8

Related

ENSPTRP00000072434.1

Conserved Domains (4) summary

smart00020
Location:494 → 716

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:210 → 290

KR; Kringle domain

cd00108
Location:388 → 470

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_009453450.5 → XP_009451725.1 hepatocyte growth factor isoform X4

See identical proteins and their annotated locations for XP_009451725.1

UniProtKB/TrEMBL

A0A2J8LGB1, A0A8I3B0W8, H2QUU8, K7AVX1, K7BAC9

Conserved Domains (4) summary

smart00020
Location:489 → 711

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:205 → 285

KR; Kringle domain

cd00108
Location:383 → 465

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_063815425.1 → XP_063671495.1 hepatocyte growth factor isoform X1

UniProtKB/TrEMBL

A0A2I3S7L0
XM_063815426.1 → XP_063671496.1 hepatocyte growth factor isoform X2
XM_063815429.1 → XP_063671499.1 hepatocyte growth factor isoform X8
XM_063815428.1 → XP_063671498.1 hepatocyte growth factor isoform X5
XM_003318558.5 → XP_003318606.1 hepatocyte growth factor isoform X6

See identical proteins and their annotated locations for XP_003318606.1

UniProtKB/TrEMBL

A0A2J8LGB3, A0A6D2W865, K7CWX4

Related

ENSPTRP00000073628.1

Conserved Domains (2) summary

smart00130
Location:210 → 289

KR; Kringle domain

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
XM_009453451.4 → XP_009451726.1 hepatocyte growth factor isoform X7

See identical proteins and their annotated locations for XP_009451726.1

UniProtKB/TrEMBL

A0A2J8LGB0

Conserved Domains (2) summary

smart00130
Location:205 → 284

KR; Kringle domain

cd00129
Location:39 → 122

PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...