EGFR epidermal growth factor receptor [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: EGFRprovided by VGNC
Official Full Name: epidermal growth factor receptorprovided by VGNC
Primary source: VGNC:VGNC:4334
Locus tag: CK820_G0044415
See related: Ensembl:ENSPTRG00000019196
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	6	NC_072404.2 (60796026..60989002)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	7	NC_072405.1 (58433460..58626457)

Chromosome 6 - NC_072404.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

HSC215_(7Gr546mb) (e-PCR)
- UniSTS:255240

SHGC-106249 (e-PCR)
- UniSTS:169737

WI-21765 (e-PCR)
- UniSTS:69135

SHGC-84087 (e-PCR)
- UniSTS:104732

GDB:6028548 (e-PCR)
- UniSTS:72992

D7S1988 (e-PCR)
- UniSTS:49706

GDB:4585359 (e-PCR)
- UniSTS:41265

RH11126 (e-PCR)
- UniSTS:58166

D7S2357 (e-PCR)
- UniSTS:45113

RH71234 (e-PCR)
- UniSTS:41530

Egfr (e-PCR), detects polymorphism
- UniSTS:472898

RH65062 (e-PCR)
- UniSTS:84805

D7S2066E (e-PCR)
- UniSTS:151119

EGFR_3293 (e-PCR)
- UniSTS:462174

EGFR (e-PCR)
- UniSTS:59743

D7S2935 (e-PCR)
- UniSTS:56178

D7S2550 (e-PCR), detects polymorphism
- UniSTS:5237

SHGC-57944 (e-PCR)
- UniSTS:18550

RH17519 (e-PCR)
- UniSTS:22914

GDB:181540 (e-PCR)
- UniSTS:155266

RH12420 (e-PCR)
- UniSTS:67459

GDB:4585323 (e-PCR)
- UniSTS:79769

RH119810 (e-PCR)
- UniSTS:133285

RH120939 (e-PCR)
- UniSTS:133798

G31779 (e-PCR)
- UniSTS:1218

SHGC-58591 (e-PCR)
- UniSTS:94411

SHGC-58597 (e-PCR)
- UniSTS:94416

GDB:1317670 (e-PCR)
- UniSTS:10965

SHGC-32574 (e-PCR)
- UniSTS:79840

SHGC-148394 (e-PCR)
- UniSTS:176370

SHGC-149653 (e-PCR)
- UniSTS:177141

RH46070 (e-PCR)
- UniSTS:4086

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables epidermal growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: epidermal growth factor receptor

Names: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

XP_001156264.1

EC 2.7.10.1

XP_054543526.1

EC 2.7.10.1

XP_519102.3

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

60796026..60989002

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_519102.9 → XP_519102.3 epidermal growth factor receptor isoform X1

See identical proteins and their annotated locations for XP_519102.3

UniProtKB/TrEMBL

A0A2I3RYF9, A0A2I3T5Z5, A0A2J8JU32, A0A6D2XY58

Related

ENSPTRP00000069741.1

Conserved Domains (5) summary

cd12093
Location:634 → 677

TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase

cd05108
Location:704 → 1016

PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor

pfam00757
Location:185 → 335

Furin-like; Furin-like cysteine rich region

pfam01030
Location:57 → 168

Recep_L_domain; Receptor L domain

pfam14843
Location:505 → 637

GF_recep_IV; Growth factor receptor domain IV
XM_001156264.8 → XP_001156264.1 epidermal growth factor receptor isoform X3

UniProtKB/TrEMBL

A0A2I3T899, A0A2I3TRV3, A0A2J8JU37, A0A2J8JU42, A0A6D2VT46, A0A6D2W718

Related

ENSPTRP00000085471.1

Conserved Domains (3) summary

pfam00757
Location:185 → 335

Furin-like; Furin-like cysteine rich region

pfam01030
Location:57 → 168

Recep_L_domain; Receptor L domain

pfam14843
Location:505 → 627

GF_recep_IV; Growth factor receptor domain IV
XM_054687551.2 → XP_054543526.1 epidermal growth factor receptor isoform X2