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PDE4D phosphodiesterase 4D [ Pan troglodytes (chimpanzee) ]

Gene ID: 461860, updated on 3-Apr-2024

Summary

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Official Symbol
PDE4Dprovided by VGNC
Official Full Name
phosphodiesterase 4Dprovided by VGNC
Primary source
VGNC:VGNC:54161
Locus tag
CK820_G0037952
See related
Ensembl:ENSPTRG00000016900
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (54093349..55659546)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (55272459..56077638)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 7 Neighboring gene uncharacterized LOC134809959 Neighboring gene DEP domain containing 1B Neighboring gene protein SET-like Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene microRNA mir-582 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like Neighboring gene uncharacterized LOC107974959 Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene RAB3C, member RAS oncogene family Neighboring gene uncharacterized LOC129144161

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cardiac muscle cell contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D; 3',5'-cyclic-AMP phosphodiesterase 4D
Names
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
XP_016810031.1
XP_016810033.1
XP_016810034.1
XP_016810037.1
XP_016810039.1
XP_016810040.1
XP_054541047.1
XP_054541049.1
XP_054541050.2
XP_063666492.1
XP_063666493.1
XP_063666494.1
XP_063666495.1
XP_063666496.1
XP_063666497.1
XP_063666498.1
XP_063666499.1
XP_063666500.1
XP_063666501.1
XP_063666502.1
XP_063666504.1
XP_063666505.1
XP_063666506.1
XP_063666507.1
XP_063666508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    54093349..55659546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063810423.1 → XP_063666493.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  2. XM_063810422.1 → XP_063666492.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  3. XM_063810426.1 → XP_063666496.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  4. XM_063810437.1 → XP_063666507.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X12

  5. XM_063810436.1 → XP_063666506.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X11

  6. XM_063810432.1 → XP_063666502.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  7. XM_063810428.1 → XP_063666498.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  8. XM_063810430.1 → XP_063666500.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  9. XM_063810438.1 → XP_063666508.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X12

  10. XM_063810425.1 → XP_063666495.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  11. XM_063810434.1 → XP_063666504.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

  12. XM_063810431.1 → XP_063666501.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X3

  13. XM_063810424.1 → XP_063666494.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  14. XM_063810429.1 → XP_063666499.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  15. XM_063810427.1 → XP_063666497.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    A0A2I3RTQ4, A0A2J8KKZ0, A0A6D2XWP9

  16. XM_054685074.2 → XP_054541049.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X13

  17. XM_054685075.2 → XP_054541050.2  3',5'-cyclic-AMP phosphodiesterase 4D isoform X14

  18. XM_016954542.4 → XP_016810031.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X2

    UniProtKB/TrEMBL
    A0A2I3RKV3, A0A2J8KKX2, A0A2J8KKZ8, A0A6D2W6E7
    Related
    ENSPTRP00000065319.1
    Conserved Domains (2) summary
    pfam00233
    Location:397 → 638
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:159 → 275
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  19. XM_063810435.1 → XP_063666505.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X8

  20. XM_054685072.2 → XP_054541047.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X7

    UniProtKB/TrEMBL
    A0A2J8KKZ1, A0A6D2WRU2, H2RBC5

  21. XM_016954544.4 → XP_016810033.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

    UniProtKB/TrEMBL
    A0A2I3S3N4, A0A2J8KKZ8, A0A2J8KL03, A0A6D2W1W2
    Related
    ENSPTRP00000071610.1
    Conserved Domains (2) summary
    pfam00233
    Location:351 → 592
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:113 → 229
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  22. XM_016954548.4 → XP_016810037.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X5

    UniProtKB/TrEMBL
    A0A2J8KKX4, A0A2J8KKZ8, A0A6D2XSV2, H2QZM9
    Related
    ENSPTRP00000039216.5
    Conserved Domains (1) summary
    pfam00233
    Location:339 → 576
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  23. XM_016954545.4 → XP_016810034.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X6

    UniProtKB/TrEMBL
    A0A2I3TMN1, A0A2J8KKX9, A0A2J8KKZ8, A0A6D2WKG5
    Related
    ENSPTRP00000090164.1
    Conserved Domains (2) summary
    pfam00233
    Location:331 → 572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:93 → 209
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  24. XM_016954551.4 → XP_016810040.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X10

    UniProtKB/TrEMBL
    A0A2I3RA89, A0A2I3RLN1, A0A2J8KKY2, A0A6D2XFY8
    Related
    ENSPTRP00000061535.1
    Conserved Domains (2) summary
    pfam00233
    Location:159 → 400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 37
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  25. XM_016954550.4 → XP_016810039.1  3',5'-cyclic-AMP phosphodiesterase 4D isoform X9

    UniProtKB/TrEMBL
    A0A2I3RLN1, A0A2I3TSM8, A0A2J8KKW7, A0A6D2WZH3
    Related
    ENSPTRP00000092269.1
    Conserved Domains (2) summary
    pfam00233
    Location:170 → 411
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RNA

  1. XR_010156913.1 RNA Sequence

Nucleotide Protein
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