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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 461836, updated on 29-Mar-2024

Summary

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Official Symbol
PIK3R1provided by VGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 1provided by VGNC
Primary source
VGNC:VGNC:13565
Locus tag
CK820_G0034249
See related
Ensembl:ENSPTRG00000016940
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (46352983..46463501, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (46765226..46878377, complement)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107974653 Neighboring gene uncharacterized LOC104006415 Neighboring gene uncharacterized LOC107974715 Neighboring gene U6 spliceosomal RNA Neighboring gene elongation factor 1-beta-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
phosphoinositide-3-kinase, regulatory subunit, polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    46352983..46463501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054684299.2 → XP_054540274.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3SIY1, A0A2J8L144, A0A6D2Y6S6

  2. XM_009449067.5 → XP_009447342.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_009447342.1

    UniProtKB/TrEMBL
    A0A2I3SIY1, A0A2J8L144, A0A6D2Y6S6
    Conserved Domains (5) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

  3. XM_517729.9 → XP_517729.2  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_517729.2

    UniProtKB/TrEMBL
    A0A2I3SIY1, A0A2J8L144, A0A6D2Y6S6
    Related
    ENSPTRP00000076964.1
    Conserved Domains (5) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...

  4. XM_054684298.2 → XP_054540273.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A2I3SIY1, A0A2J8L144, A0A6D2Y6S6

  5. XM_003950543.6 → XP_003950592.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    See identical proteins and their annotated locations for XP_003950592.1

    UniProtKB/TrEMBL
    A0A2J8L138, A0A6D2X492, K7C6D6
    Related
    ENSPTRP00000068806.1
    Conserved Domains (3) summary
    cd09930
    Location:317 → 420
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:25 → 135
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:140 → 300
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha

  6. XM_003950542.6 → XP_003950591.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    See identical proteins and their annotated locations for XP_003950591.1

    UniProtKB/TrEMBL
    A0A2J8L132, A0A6D2VYT9, H2QR04, K7D5X9
    Related
    ENSPTRP00000029009.5
    Conserved Domains (3) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
Nucleotide Protein
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