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PDE8B phosphodiesterase 8B [ Pan troglodytes (chimpanzee) ]

Gene ID: 461796, updated on 3-Apr-2024

Summary

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Official Symbol
PDE8Bprovided by VGNC
Official Full Name
phosphodiesterase 8Bprovided by VGNC
Primary source
VGNC:VGNC:4125
Locus tag
CK820_G0009396
See related
Ensembl:ENSPTRG00000017010
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See PDE8B in Genome Data Viewer
Location:
chromosome: 5
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 4 NC_072402.2 (38610252..38857472, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 5 NC_072403.1 (39027245..39275061, complement)

Chromosome 4 - NC_072402.2Genomic Context describing neighboring genes Neighboring gene orthopedia homeobox Neighboring gene WD repeat domain 41 Neighboring gene large ribosomal subunit protein uL30-like Neighboring gene alpha-aminoadipic semialdehyde dehydrogenase-like Neighboring gene high mobility group protein B1-like Neighboring gene small nucleolar RNA SNORA47 Neighboring gene zinc finger BED-type containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
high-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
XP_016808597.1
XP_016808598.1
XP_016808599.1
XP_016808600.1
XP_016808601.1
XP_054540258.1
XP_054540259.1
XP_054540260.1
XP_054540261.1
XP_517695.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    38610252..38857472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054684286.2 → XP_054540261.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X9

  2. XM_054684284.2 → XP_054540259.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

  3. XM_517695.9 → XP_517695.4  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A2J8NNA3
    Conserved Domains (3) summary
    cd00130
    Location:183 → 275
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:513 → 760
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:178 → 276
    PAS_9; PAS domain

  4. XM_054684283.2 → XP_054540258.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

  5. XM_016953110.4 → XP_016808599.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    UniProtKB/TrEMBL
    A0A2I3SNP4, A0A2I3T9V1, A0A2J8NN97, A0A2J8NNC2, A0A6D2VZ19, A0A6D2X5Q8
    Related
    ENSPTRP00000078548.1
    Conserved Domains (2) summary
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:567 → 814
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  6. XM_016953109.4 → XP_016808598.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    UniProtKB/TrEMBL
    A0A2I3T9V1, A0A2J8NNC2, A0A6D2VZ19
    Related
    ENSPTRP00000086007.1

  7. XM_016953111.4 → XP_016808600.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

    UniProtKB/TrEMBL
    A0A2I3T9V1, A0A2I3TLX7, A0A2J8NNA4, A0A2J8NNC2, A0A6D2VZ19, A0A6D2XNM7
    Related
    ENSPTRP00000089903.1
    Conserved Domains (3) summary
    PHA02597
    Location:158 → 311
    30.2; hypothetical protein; Provisional
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:517 → 764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

  8. XM_016953108.4 → XP_016808597.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/TrEMBL
    A0A2I3SCR9, A0A2I3T9V1, A0A2J8NN85, A0A2J8NNC2, A0A6D2VZ19, A0A6D2WQU8
    Related
    ENSPTRP00000074828.1
    Conserved Domains (3) summary
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam00233
    Location:614 → 861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:280 → 377
    PAS_9; PAS domain

  9. XM_016953112.4 → XP_016808601.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

    UniProtKB/TrEMBL
    H2QR45
    Related
    ENSPTRP00000029126.5

  10. XM_054684285.2 → XP_054540260.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X10

Nucleotide Protein
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