FGA fibrinogen alpha chain [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: FGAprovided by VGNC
Official Full Name: fibrinogen alpha chainprovided by VGNC
Primary source: VGNC:VGNC:599
Locus tag: CK820_G0016983
See related: Ensembl:ENSPTRG00000016535
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	3	NC_072401.2 (156390979..156397808, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	4	NC_072402.1 (156350381..156357211, complement)

Chromosome 3 - NC_072401.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

GDB:374018 (e-PCR)
- UniSTS:156934

SHGC-59324 (e-PCR)
- UniSTS:74254

SHGC-32984 (e-PCR)
- UniSTS:49425

GDB:215015 (e-PCR)
- UniSTS:156198

GDB:633003 (e-PCR)
- UniSTS:158506

D4S2882 (e-PCR)
- UniSTS:10296

RH18276 (e-PCR)
- UniSTS:37702

G33492 (e-PCR)
- UniSTS:73328

STS-H72060 (e-PCR)
- UniSTS:42096

FGA_3978 (e-PCR)
- UniSTS:462193

D4S3286 (e-PCR)
- UniSTS:1930

D4S3155 (e-PCR)
- UniSTS:60310

GDB:187393 (e-PCR)
- UniSTS:155550

SHGC-50337 (e-PCR)
- UniSTS:65487

STS-H58121 (e-PCR)
- UniSTS:4838

SHGC-59770 (e-PCR)
- UniSTS:12018

FGA (e-PCR)
- UniSTS:240635

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in blood coagulation, common pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info	PubMed
involved_in platelet activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in platelet aggregation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of peptide hormone secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein polymerization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibrinogen alpha chain

Names: fibrinogen, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

156390979..156397808 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001136067.8 → XP_001136067.1 fibrinogen alpha chain

UniProtKB/TrEMBL

A0A2J8MUS6, A0A6D2W5W3, H2QQB5

Related

ENSPTRP00000028386.3

Conserved Domains (3) summary

cd00087
Location:630 → 863

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:50 → 187

Fib_alpha; Fibrinogen alpha/beta chain family

pfam12160
Location:445 → 509

Fibrinogen_aC; Fibrinogen alpha C domain