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LEF1 lymphoid enhancer binding factor 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 461425, updated on 3-Apr-2024

Summary

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Official Symbol
LEF1provided by VGNC
Official Full Name
lymphoid enhancer binding factor 1provided by VGNC
Primary source
VGNC:VGNC:6477
Locus tag
CK820_G0024114
See related
Ensembl:ENSPTRG00000016352
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 3 NC_072401.2 (109508215..109628298, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 4 NC_072402.1 (109508196..109632209, complement)

Chromosome 3 - NC_072401.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104006161 Neighboring gene cytochrome P450 family 2 subfamily U member 1 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene uncharacterized LOC129143758 Neighboring gene uncharacterized LOC134809903 Neighboring gene exocyst complex component 7-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lymphoid enhancer-binding factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072401.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    109508215..109628298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063809722.1 → XP_063665792.1  lymphoid enhancer-binding factor 1 isoform X13

  2. XM_009448108.5 → XP_009446383.1  lymphoid enhancer-binding factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A2I3SCB8
    Conserved Domains (2) summary
    cd01388
    Location:270 → 341
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  3. XM_517386.8 → XP_517386.2  lymphoid enhancer-binding factor 1 isoform X7

    See identical proteins and their annotated locations for XP_517386.2

    UniProtKB/TrEMBL
    A0A2I3SCB8, A0A2J8M2G2
    Conserved Domains (2) summary
    cd01388
    Location:270 → 341
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  4. XM_063809719.1 → XP_063665789.1  lymphoid enhancer-binding factor 1 isoform X10

    UniProtKB/TrEMBL
    A0A2I3T0W4, A0A2J8M2H9, A0A6D2Y3G0

  5. XM_009448109.5 → XP_009446384.1  lymphoid enhancer-binding factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A2I3SCB8
    Conserved Domains (2) summary
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding
    cl00082
    Location:298 → 336
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  6. XM_009448113.5 → XP_009446388.1  lymphoid enhancer-binding factor 1 isoform X9

    UniProtKB/TrEMBL
    A0A2I3SCB8
    Conserved Domains (2) summary
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding
    cl00082
    Location:298 → 333
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

  7. XM_063809720.1 → XP_063665790.1  lymphoid enhancer-binding factor 1 isoform X11

  8. XM_009448107.5 → XP_009446382.1  lymphoid enhancer-binding factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A2I3SCB8
    Conserved Domains (2) summary
    cd01388
    Location:298 → 369
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  9. XM_009448110.5 → XP_009446385.1  lymphoid enhancer-binding factor 1 isoform X4

    See identical proteins and their annotated locations for XP_009446385.1

    UniProtKB/TrEMBL
    A0A2I3SCB8, A0A2I3SSM9
    Related
    ENSPTRP00000079959.1
    Conserved Domains (2) summary
    cd01388
    Location:298 → 369
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding

  10. XM_063809718.1 → XP_063665788.1  lymphoid enhancer-binding factor 1 isoform X5

    UniProtKB/TrEMBL
    A0A2I3S5R9, A0A2J8M2H0, A0A6D2VUE5

  11. XM_063809723.1 → XP_063665793.1  lymphoid enhancer-binding factor 1 isoform X14

  12. XM_003310432.6 → XP_003310480.1  lymphoid enhancer-binding factor 1 isoform X15

    See identical proteins and their annotated locations for XP_003310480.1

    UniProtKB/TrEMBL
    A0A2J8M2G7, A0A6D2VTJ0, H2QQ05
    Related
    ENSPTRP00000028092.5
    Conserved Domains (2) summary
    cd01388
    Location:202 → 273
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08347
    Location:6 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  13. XM_009448111.5 → XP_009446386.1  lymphoid enhancer-binding factor 1 isoform X6

    Conserved Domains (2) summary
    cd01388
    Location:230 → 301
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 145
    CTNNB1_binding; N-terminal CTNNB1 binding

  14. XM_063809721.1 → XP_063665791.1  lymphoid enhancer-binding factor 1 isoform X12

  15. XM_009448112.5 → XP_009446387.1  lymphoid enhancer-binding factor 1 isoform X8

    UniProtKB/TrEMBL
    A0A2I3SCB8
    Related
    ENSPTRP00000074142.1
    Conserved Domains (2) summary
    cd01388
    Location:298 → 369
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam08347
    Location:1 → 213
    CTNNB1_binding; N-terminal CTNNB1 binding
Nucleotide Protein
Heading Accession and Version

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